Evidence map›Paper›PMID 33869150›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Dynamic Endothelial Stalk Cell-Matrix Interactions Regulate Angiogenic Sprout Diameter.

William Y Wang, Evan H Jarman, Daphne Lin, Brendon M Baker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. The Chemistry and Biology of Collagen Hybridization.Journal of the American Chemical Society · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Mechanical regulation of the early stages of angiogenesis.Journal of the Royal Society, Interface · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

William Y WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Evan H JarmanDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Daphne LinDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.
Brendon M BakerDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.

Funding

Mechanics of fibrosis in 3D biomimetic extracellular matricesR00HL124322 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKER, BRENDON M · 2017 to 2019
$747k
Mechanics of fibrosis in 3D biomimetic extracellular matricesK99HL124322 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BAKER, BRENDON M · 2015 to 2016
$261k
NHLBI NIH HHS K99 HL124322NHLBI NIH HHS R00 HL124322
6 · The paper itself

Abstract

Angiogenesis is a complex, multicellular process that involves bidirectional interactions between extracellular matrix (ECM) and collectively invading endothelial cell (EC) sprouts that extend the microvasculature during development, wound healing, and disease processes. While many aspects of angiogenesis have been well studied, the relationship between endothelial sprout morphology and subsequent neovessel function remains relatively unknown. Here, we investigated how various soluble and physical matrix cues that regulate endothelial sprouting speed and proliferation correspond to changes in sprout morphology, namely, sprout stalk diameter. We found that sprout stalk cells utilize a combination of cytoskeletal forces and proteolysis to physically compact and degrade the surrounding matrix, thus creating sufficient space in three-dimensional (3D) ECM for lateral expansion. As increasing sprout diameter precedes lumenization to generate perfusable neovessels, this work highlights how dynamic endothelial stalk cell-ECM interactions promote the generation of functional neovessels during sprouting angiogenesis to provide insight into the design of vascularized, implantable biomaterials.

Indexed as

angiogenesiscell migrationcell proliferationcytoskeletal forcesendothelial cellextracellular matrixmicrofluidic “lab-on-a-chip,”proteolysis

Identifiers

PMID33869150
PMCPMC8044977

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.