Evidence map›Paper›PMID 33868988›Full record

ArticleFrontiers in oncology2021

Radiomics Analysis Based on Contrast-Enhanced MRI for Prediction of Therapeutic Response to Transarterial Chemoembolization in Hepatocellular Carcinoma.

Ying Zhao, Nan Wang, Jingjun Wu, Qinhe Zhang, Tao Lin, Yu Yao, Zhebin Chen, Man Wang, Liuji Sheng, Jinghong Liu and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  7. Longitudinal CE-MRI-based Siamese network with machine learning to predict tumor response in HCC after DEB-TACE.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Ying ZhaoDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Nan WangDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Jingjun WuDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Qinhe ZhangDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Tao LinDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Yu YaoChengdu Institute of Computer Application, Chinese Academy of Sciences, Chengdu, China.
Zhebin ChenChengdu Institute of Computer Application, Chinese Academy of Sciences, Chengdu, China.
Man WangDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Liuji ShengDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Jinghong LiuDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Qingwei SongDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Feng WangDepartment of Interventional Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Xiangbo AnDepartment of Interventional Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Yan GuoLife Sciences, GE Healthcare, Shanghai, China.
Xin LiGlobal Research, GE Healthcare, Shanghai, China.
Tingfan WuClinical Education Team (CET), GE Healthcare, Shanghai, China.
Ai Lian LiuDepartment of Radiology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
Dalian Medical University · CNFirst Affiliated Hospital of Dalian Medical University · CNUnited Imaging Healthcare (China) · CNUniversity of Chinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the role of contrast-enhanced magnetic resonance imaging (CE-MRI) radiomics for pretherapeutic prediction of the response to transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC).

methodsOne hundred and twenty-two HCC patients (objective response,

resultsAmong all radiomics models, the three-phase radiomics model exhibited better performance in the training cohort with an area under the curve (AUC) of 0.838 (95% confidence interval (CI), 0.753 - 0.922), which was verified in the validation cohort (AUC, 0.833; 95% CI, 0.691 - 0.975). The combined model that integrated the three-phase radiomics score and clinical-radiological risk factors (total bilirubin, tumor shape, and tumor encapsulation) showed excellent calibration and predictive capability in the training and validation cohorts with AUCs of 0.878 (95% CI, 0.806 - 0.950) and 0.833 (95% CI, 0.687 - 0.979), respectively, and showed better predictive ability (

conclusionCE-MRI radiomics analysis may serve as a promising and noninvasive tool to predict therapeutic response to TACE in HCC, which will facilitate the individualized follow-up and further therapeutic strategies guidance in HCC patients.

Indexed as

hepatocellular carcinomamagnetic resonance imagingradiomicstherapeutic responsetransarterial chemoembolization

Identifiers

PMID33868988
PMCPMC8045706
OpenAlexW3147893827

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.