ArticlePlastic and reconstructive surgery. Global open2021
Indocyanine Green Angiography Precise Marking for Indeterminate Burn Excision: A Prospective, Multi-centered, Double-blinded Study.
Article in Plastic and reconstructive surgery. Global open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Optical, Tomographic, and Mass Spectrometry Imaging Methods for Burn Wounds: Capabilities, Limitations, and Clinical Potential.Biomedicines · 2026Review
- The Diagnostic Value of Indocyanine Green in the Assessment of Depth of Burn Injuries: A Systematic Review.European burn journal · 2026Review
- Evaluation of Burn Depth using Indocyanine Green: Discrepancies Between Macroscopic Visualization and the Microenvironment.Plastic and reconstructive surgery · 2026Article
- Assessing Burn Depth by Indocyanine Green Angiography: A Systematic Review and Algorithm for Clinical Use.Annals of burns and fire disasters · 2026Article
- Indocyanine green fluorescence-guided surgery in acute settings: state-of-the art.Frontiers in surgery · 2026Review
- Utility of indocyanine green fluorescent dye in emergency general surgery: a review of the contemporary literature.Frontiers in surgery · 2024Review
- Application of indocyanine green in surgery: A review of current evidence and implementation in trauma patients.World journal of gastrointestinal surgery · 2023Review
- The Role of ICG Angiography in Decision Making About Skin-Sparing in Pediatric Acute Trauma.Frontiers in pediatrics · 2022Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDuring burn excision, the clinical judgment whether to excise or not excise the area with indeterminate burn depth is difficult. Indocyanine green angiography (ICGA) has been reported to provide high accuracy in diagnosing indeterminate burns. This study aims to evaluate the complete wound closures in both short-term and long-term outcomes after using ICGA precise marking to guide indeterminate burn excision.
methodsThis was a prospective, multi-centered, double-blinded, experimental study. The participants were admitted to the hospital with indeterminate burn wounds. ICGA precise marking was performed. The deep second-degree burn was painted, excised, and subsequently covered with skin grafts and measured on day 5. The superficial burns were measured on day 21. All wounds were followed-up at two months.
resultsThirty indeterminate burn sites were included in this study. Using ICGA precise marking, the overall rate of short-term complete wound closure, which combined superficial and deep burns, was found to be as high as 96.7% (29/30). The long-term complete wound closures at two months confirmed the short-term result and yielded 100.0% of complete wound closure. The complete wound closures between the short-term and long-term measurements were not significantly different (
conclusionsUsing ICGA precise marking to guide indeterminate burn excision resulted in an excellent rate of complete wound closure and an insignificant difference between short-term and long-term wound outcomes. ICGA is a competent method to aid decision-making in burn surgery of the indeterminate area.
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Registered trials
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