Evidence map›Paper›PMID 33868687›Full record

ArticleClinical & translational immunology2021

Impact of maternal engrafted cytomegalovirus-specific CD8

June-Young Koh, Sang-Bo Lee, Borahm Kim, Younhee Park, Jong Rak Choi, Sohee Son, Yae-Jean Kim, Seung Min Hahn, Jong Gyun Ahn, Ji-Man Kang and 1 more

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical & translational immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

June-Young KohGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea.ORCID https://orcid.org/0000-0002-2043-6624
Sang-Bo LeeDepartment of Pediatrics Severance Children's Hospital Yonsei University College of Medicine Seoul Republic of Korea.
Borahm KimDepartment of Laboratory Medicine Korea University College of Medicine Seoul Republic of Korea.
Younhee ParkDepartment of Laboratory Medicine Yonsei University College of Medicine Seoul Republic of Korea.
Jong Rak ChoiDepartment of Laboratory Medicine Yonsei University College of Medicine Seoul Republic of Korea.
Sohee SonDepartment of Pediatrics Samsung Medical Center Sungkyunkwan University Seoul Republic of Korea.
Yae-Jean KimDepartment of Pediatrics Samsung Medical Center Sungkyunkwan University Seoul Republic of Korea.
Seung Min HahnDepartment of Pediatrics Severance Children's Hospital Yonsei University College of Medicine Seoul Republic of Korea.
Jong Gyun AhnDepartment of Pediatrics Severance Children's Hospital Yonsei University College of Medicine Seoul Republic of Korea.
Ji-Man KangDepartment of Pediatrics Severance Children's Hospital Yonsei University College of Medicine Seoul Republic of Korea.ORCID https://orcid.org/0000-0002-0678-4964
Eui-Cheol ShinGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon Republic of Korea.ORCID https://orcid.org/0000-0002-6308-9503
Yonsei University · KRKorea Advanced Institute of Science and Technology · KRSamsung Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesIn patients with severe combined immunodeficiency (SCID), the immune system often fails to eradicate maternal cells that enter the foetus via the placenta, resulting in transplacental maternal engraftment (TME) syndrome. However, the clinical significance of TME has not been comprehensively elucidated.

methodsHere, we describe a patient with SCID with a novel frameshift

resultsIn our patient, the maternal engrafted CD8

conclusionOur findings elucidate a possible functional role of TME in controlling CMV infection in patient with SCID and suggest an optimal strategy for donor selection in patients with SCID with TME.

Indexed as

CD8+ T cellscytomegalovirus infectionhaploidentical haematopoietic stem cell transplantationsevere combined immunodeficiencytransplacental maternal engraftment

Identifiers

PMID33868687
PMCPMC8043123
OpenAlexW3155165449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.