Evidence map›Paper›PMID 33868550›Full record

ArticleThe Neurohospitalist2021

Neurological Outcomes of Patients With Mycotic Aneurysms in Infective Endocarditis.

Hang Shi, Neal S Parikh, Charles Esenwa, Richard Zampolin, Harsh Shah, Farid Khasiyev, Ives Valenzuela, Sean Lavine, Jose Gutierrez, Joshua Willey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Neurohospitalist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Hang ShiDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-2330-7438
Neal S ParikhClinical and Translational Neuroscience Unit, Feil Family Brain & Mind Research Institute and Weill Cornell Medicine, New York, NY, USA.ORCID https://orcid.org/0000-0002-8802-2380
Charles EsenwaThe Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA.
Richard ZampolinDepartment of Radiology (Neuroradiology), Albert Einstein College of Medicine, Bronx, NY, USA.
Harsh ShahCollege of Medicine, University of Florida, Gainesville, FL, USA.
Farid KhasiyevDivision of Vascular Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Ives ValenzuelaDepartment of Ophthalmology, Columbia University Irving Medical Center, New York, NY, USA.
Sean LavineDepartments of Neurological Surgery and Radiology, Columbia University Irving Medical Center, New York, NY, USA.
Jose GutierrezDivision of Vascular Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Joshua WilleyDivision of Vascular Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.ORCID https://orcid.org/0000-0001-5180-2044
Columbia University Irving Medical Center · USAlbert Einstein College of Medicine · USCornell University · USEmory University · USUniversity of Florida · US

Funding

NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

background and purposeMycotic aneurysms (MA) are rare neurovascular complications of infective endocarditis (IE). The natural history and outcomes of MA under contemporary medical therapy have not been well characterized. The purpose of this study is to describe treatments and outcomes of patients with ruptured and unruptured MA in IE, specifically in relation to medical versus surgical/endovascular treatment.

methodsRetrospective chart review was performed at 3 US academic medical centers of adult patients with IE and MA. Information was collected regarding risk factors, imaging, treatments, and outcomes, including ischemic stroke, intracerebral hemorrhage, MA size changes, and inhospital mortality.

resultsThirty-five patients with IE had 63 MA. Nineteen patients had at least one ruptured MA; 13 patients underwent invasive treatment and 6 received antibiotics alone. Of 19 patients on antibiotics alone (6 with at least one ruptured MA and 13 with unruptured MA), 14 underwent repeat imaging and 5 had enlarging MA. Of 16 patients treated invasively, 2 had unruptured MA initially treated with antibiotics but ultimately underwent intervention. No MA ruptured after aneurysm discovery. Fifteen patients underwent cardiothoracic surgery (CTS), of which 11 had unsecured MA and 4 had secured MA. No patients suffered perioperiative neurological events attributable to their MA. Three patients treated with antibiotics alone and 3 patients treated invasively died from causes unrelated to their MAs.

conclusionsFor patients with unruptured MA, treatment with antibiotics alone may have similar outcomes to invasive treatment. Further investigation is warranted to determine the risk of undergoing CTS with unsecured MA.

Indexed as

bacterial endocarditiscardiothoracic surgeryinfected aneurysminfective endocarditismicrobial aneurysmmycotic aneurysmsubarachnoid hemorrhage

Identifiers

PMID33868550
PMCPMC8022178
OpenAlexW3034568429

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.