ArticleCellular and molecular bioengineering2021
Immune Cell Paracrine Signaling Drives the Neutrophil Response to
Article in Cellular and molecular bioengineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The trial behind it
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Leveraging Microphysiological Systems to Facilitate Neutrophil-Based Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Interleukin-6 regulates the neutrophil response to diverse bacteria.Frontiers in immunology · 2026Article
- Human M-MDSCs impair neutrophil migration in the infectious microenvironment.Journal of leukocyte biology · 2025Article
- THP-1 Macrophages Limit Neutrophil Transendothelial Migration in a Model Infection.Cellular and molecular bioengineering · 2024Article
- Modeling lung endothelial dysfunction in sepsis-associated ARDS using a microphysiological system.Physiological reports · 2024Article
- Diverse bacteria elicit distinct neutrophil responses in a physiologically relevant model of infection.iScience · 2024Article
- Microphysiological head and neck cancer model identifies novel role of lymphatically secreted monocyte migration inhibitory factor in cancer cell migration and metabolism.Biomaterials · 2023Article
- Integration of immune cells in organs-on-chips: a tutorial.Frontiers in bioengineering and biotechnology · 2023Review
- Simplified Cell Magnetic Isolation Assisted SCMicromachines · 2022Article
- A Fun-Guide to Innate Immune Responses to Fungal Infections.Journal of fungi (Basel, Switzerland) · 2022Review
- Neutrophil phenotypes and functions in cancer: A consensus statement.The Journal of experimental medicine · 2022Review
- Neutrophils: Amoeboid Migration and Swarming Dynamics in Tissues.Frontiers in cell and developmental biology · 2022Review
- Microphysiological Systems for Studying Cellular Crosstalk During the Neutrophil Response to Infection.Frontiers in immunology · 2021Review
- Gram-Negative BacteriaFrontiers in pharmacology · 2021Article
- Microfluidic Systems to Study Neutrophil Forward and Reverse Migration.Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
introductionNeutrophils act as first responders during an infection, following signals from the pathogen as well as other host cells to migrate from blood vessels to the site of infection. This tightly regulated process is critical for pathogen clearance and, in many cases, eliminates the pathogen without the need for an additional immune response. It is, therefore, critical to understand what signals drive neutrophil migration to infection in a physiologically relevant environment.
methodsIn this study, we used an infection-on-a-chip model to recapitulate many important aspects of the infectious microenvironment including an endothelial blood vessel, an extracellular matrix, and the environmental fungal pathogen
resultsWe found that
conclusionsTaken together, these results suggest that paracrine signaling from both monocytes and neutrophils plays an important role in driving the neutrophil response to
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.