ArticleFrontiers in genetics2021
Type 2 Diabetes and Cognitive Status in the Health and Retirement Study: A Mendelian Randomization Approach.
Article in Frontiers in genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Diabetes mellitus and risk of incident dementia in APOE ɛ4 carriers: an updated meta-analysis.BMC neuroscience · 2024Pooled it
- Assessing the role of vascular risk factors in dementia: Mendelian randomization meta-analysis and comparison with observational estimates.F1000Research · 2022Pooled it
- Trajectory-Oriented Brain Vulnerability Framework for Cognitive Decline in Type 2 Diabetes.International journal of molecular sciences · 2026Review
- Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes.Frontiers in endocrinology · 2025Review
- Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.Scientific reports · 2024Article
- Risk Prediction Models for Mild Cognitive Impairment in Patients with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Review
- Mendelian randomization study of diabetes and dementia in the Million Veteran Program.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Modifiable cardiovascular risk factors and genetics for targeted prevention of dementia.European heart journal · 2023Article
- Mendelian randomization study of diabetes and dementia in the Million Veteran Program.medRxiv : the preprint server for health sciences · 2023Article
- Type 2 diabetes and glycemic traits are not causal factors of delirium: A two-sample mendelian randomization analysis.Frontiers in genetics · 2023Article
- A Diabetes Genetic Risk Score Is Associated With All-Cause Dementia and Clinically Diagnosed Vascular Dementia in the Million Veteran Program.Diabetes care · 2022Article
- Diabetes and dementia: Clinical perspective, innovation, knowledge gaps.Journal of diabetes and its complications · 2022Review
- Phenome-Wide Association Study of Polygenic Risk Score for Alzheimer's Disease in Electronic Health Records.Frontiers in aging neuroscience · 2022Article
- Race, polygenic risk and their association with incident dementia among older US adults.Brain communications · 2022Article
- Cognitive impairment in racially/ethnically diverse older adults: Accounting for sources of diagnostic bias.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundType 2 diabetes mellitus (T2DM) and dementia are leading causes of mortality and disability in the US. T2DM has been associated with dementia; however, causality has not been clearly established. This study tested inferred causality between T2DM and dementia status using a Mendelian randomization approach.
methodsParticipants (50+ years) from the 2010 wave of the Health and Retirement Study of European or African genetic ancestry were included (
resultsAmong included participants, 20.9% had T2DM and 20.7% had dementia or cognitive impairment. Among European ancestry participants, T2DM was associated with 1.66 times odds of cognitive impairment non-dementia (95% confidence interval: 1.55-1.77) relative to normal cognition. A one standard deviation increase in cumulative genetic risk for T2DM was associated with 1.30 times higher odds of T2DM (95% confidence interval: 1.10-1.52). Cumulative genetic risk for T2DM was not associated with dementia status or cognitive-impaired non-dementia in either ancestry ( DISCUSSION: Consistent with prior research, T2DM was associated with cognitive status. Prevention of T2DM and cognitive decline are both critical for public health, however, this study does not provide evidence that T2DM is causally related to impaired cognition. Additional studies in other ancestries, larger sample sizes, and longitudinal studies are needed to confirm these results.
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Registered trials
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