Evidence map›Paper›PMID 33868317›Full record

ArticleFrontiers in immunology2021

Diagnostic and Predictive Contribution of Autoantibodies Screening in a Large Series of Patients With Primary Immunodeficiencies.

Azzeddine Tahiat, Abdelghani Yagoubi, Mohamed Samir Ladj, Reda Belbouab, Samira Aggoune, Laziz Atek, Djamila Bouziane, Souhila Melzi, Chahinez Boubidi, Warda Drali and 22 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 8 institutions in 3 countries.

Azzeddine TahiatDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Abdelghani YagoubiPediatric Gastroenterology, Centre Algérois de Pédiatrie, Algiers, Algeria.
Mohamed Samir LadjDepartment of Pediatrics, Mustapha University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Reda BelbouabDepartment of Pediatrics, Mustapha University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Samira AggouneDepartment of Pediatrics, El-Harrach Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Laziz AtekDepartment of Pediatrics, El-Harrach Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Djamila BouzianeDepartment of Pediatrics, Ain Taya Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Souhila MelziDepartment of Pediatrics, Bab El-Oued University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Chahinez BoubidiDepartment of Pediatrics A, Hussein Dey University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Warda DraliDepartment of Pediatrics B, Hussein Dey University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Chafa BendahmaneDepartment of Pediatrics, Meftah Hospital, Blida, Algeria.
Hamza IguerguesdaouneDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Sihem TaguemountDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Asma SoufaneDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Asma OukilDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Abdalbasset KetfiDepartment of Pneumology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Hassen MessaoudiDepartment of Internal Medicine, Mustapha University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Nadia BoukhenfoufDepartment of Pediatrics, Rouiba Hospital, Algiers, Algeria.
Mohamed Amine IfriDepartment of Pediatrics, Thenia Hospital, Boumerdes, Algeria.
Tahar Bencharif MadaniDepartment of Pediatrics, Mansourah Hospital, Constantine, Algeria.
Hayet BelhadjDepartment of Pediatrics, Central Hospital of the Army, Algiers, Algeria.
Keltoum Nafissa BenhalaDepartment of Pediatrics A, Beni Messous University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Mokhtar KhiariDepartment of Pediatrics A, Beni Messous University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Nacera CherifDepartment of Pediatrics B, Beni Messous University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Leila SmatiDepartment of Pediatrics, Bologhine Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Zakia AradaDepartment of Pediatrics B, Hussein Dey University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Zoulikha ZeroualDepartment of Pediatrics A, Hussein Dey University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Zair BouzerarDepartment of Pediatrics, Bab El-Oued University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Ouardia IbsaineDepartment of Pediatrics, Ain Taya Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Hachemi MaoucheDepartment of Pediatrics, El-Harrach Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Rachida BoukariDepartment of Pediatrics, Mustapha University Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
Kamel DjenouhatDepartment of Medical Biology, Rouiba Hospital, Algiers Faculty of Medicine, University of Algiers 1, Algiers, Algeria.
University of Algiers 3 · DZUniversity of Algiers Benyoucef Benkhedda · DZCentre Hospitalo-Universitaire Bab El Oued · DZCentre de Recherche Nucléaire d’Alger · DZKent Hospital · USMansoura University Hospital · EGUniversity Hospital of Oran · DZUniversity of Bouira · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To evaluate the diagnostic and predictive contribution of autoantibodies screening in patients with primary immunodeficiencies (PIDs). Methods: In the present study, PID patients and healthy controls have been screened for 54 different autoantibodies. The results of autoantibodies screening in PID patients were correlated to the presence of autoimmune diseases. Results: A total of 299 PID patients were included in this study with a predominance of antibody deficiencies (27.8%) followed by immunodeficiencies affecting cellular and humoral immunity (26.1%) and complement deficiencies (22.7%). Autoimmune manifestations were present in 82 (27.4%) patients. Autoimmune cytopenia (10.4%) was the most common autoimmune disease followed by gastrointestinal disorders (10.0%), rheumatologic diseases (3.7%), and endocrine disorders (3.3%). Autoantibodies were found in 32.4% of PID patients and 15.8% of healthy controls ( Conclusion: The present study provides valuable information about the frequency and the diagnostic/predictive value of a large panel of autoantibodies in PIDs. Given the frequent association of some AIDs with certain PIDs, screening for corresponding autoantibodies would be recommended. However, positivity for autoantibodies should be interpreted with caution in patients with PIDs due to their low positive predictive value.

Indexed as

AutoimmunityAdolescentAdultAgedAged, 80 and overAntibodies, AntinuclearAutoantibodiesAutoimmune DiseasesCase-Control StudiesCeliac DiseaseChildChild, PreschoolFemaleHumansImmunity, CellularImmunity, HumoralAntibodies, AntinuclearAutoantibodiesRheumatoid Factorautoantibodyautoimmune cytopeniaceliac diseaseplatelet-bound IgMprimary immunodeficienciesscreeningtransglutaminase antibody

Identifiers

PMID33868317
PMCPMC8047634
OpenAlexW3147587307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.