Evidence map›Paper›PMID 33868279›Full record

ArticleFrontiers in immunology2021

Antigenic Challenge Influences Epigenetic Changes in Antigen-Specific T Regulatory Cells.

Dorota Iwaszkiewicz-Grzes, Magdalena Piotrowska, Mateusz Gliwinski, Zuzanna Urban-Wójciuk, Piotr Trzonkowski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Regulatory T Cells-Related Genes Are under DNA Methylation Influence.International journal of molecular sciences · 2021
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Dorota Iwaszkiewicz-GrzesDepartment of Medical Immunology, Medical University of Gdansk, Gdańsk, Poland.
Magdalena PiotrowskaDepartment of Medical Immunology, Medical University of Gdansk, Gdańsk, Poland.
Mateusz GliwinskiDepartment of Medical Immunology, Medical University of Gdansk, Gdańsk, Poland.
Zuzanna Urban-WójciukInternational Centre for Cancer Vaccine Science, University of Gdańsk, Gdańsk, Poland.
Piotr TrzonkowskiDepartment of Medical Immunology, Medical University of Gdansk, Gdańsk, Poland.
Gdańsk Medical University · PLUniversity of Gdańsk · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Human regulatory T cells (Tregs) are the fundamental component of the immune system imposing immune tolerance Methods: The analysis was pefromed in the sorted specific (SPEC, proliferating) and unspecific (UNSPEC, non-proliferating) subsets of Tregs and Teffs generated by the stimulation with monocytes loaded with either whole insulin (INS) or insulin β chain peptide 9-23 (B:9-23) or polyclonal cells stimulated with anti-CD3/anti-CD28 beads (POLY). A relative expression of crucial Tregs genes was determined by qRT-PCR. The Treg-specific demethylated region (TSDR) in FoxP3 gene methylation levels were assessed by Quantitative Methylation Specific PCR (qMSP). ELISA was used to measure genomic DNA methylation and histone H3 post-translational modifications (PTMs). Results: Tregs SPEC Conclusions: Whole insulin and insulin β chain peptide 9-23 affected epigenetic changes in CD4

Indexed as

DNA MethylationAdolescentAdultAgedAntigensCTLA-4 AntigenForkhead Transcription FactorsHistonesHumansMaleMiddle AgedPromoter Regions, GeneticT-Lymphocytes, RegulatoryYoung AdultAntigensCTLA-4 AntigenCTLA4 protein, humanForkhead Transcription FactorsFOXP3 protein, humanHistonesantigen-specificDNA methylationepigeneticsgene expressionhistone H3TSDR

Identifiers

PMID33868279
PMCPMC8044853
OpenAlexW3136593119

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.