Evidence map›Paper›PMID 33868182›Full record

ReviewFrontiers in endocrinology2021

Resistance to Thyroid Hormone Beta: A Focused Review.

Theodora Pappa, Samuel Refetoff

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 105 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Review
  4. Article
  5. medRxiv : the preprint server for health sciences · 2026
    Article
  6. Article
  7. Article
  8. Thyrotoxicosis in MCT8 deficiency.The Journal of clinical endocrinology and metabolism · 2026
    Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Theodora PappaDivision of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Boston, MA, United States.
Samuel RefetoffDepartments of Medicine, Pediatrics and Committee on Genetics, The University of Chicago, Chicago, IL, United States.
Brigham and Women's Hospital · USUniversity of Chicago · US

Funding

TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR01DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI ANTONIO C BIANCO, Alexandra Mihaela Dumitrescu · 1986 to 2026
$8.1M
THYROID PHYSIOLOGY STUDIES OF INHERITED DISORDERSR37DK015070 · NIDDK · UNIVERSITY OF CHICAGO · PI REFETOFF, SAMUEL · 1989 to 2015
$5.6M
NHLBI NIH HHS T32 HL007609NIDDK NIH HHS R01 DK015070NIDDK NIH HHS R37 DK015070
6 · The paper itself

Abstract

Resistance to thyroid hormone (RTH) is a clinical syndrome defined by impaired sensitivity to thyroid hormone (TH) and its more common form is caused by mutations in the

Indexed as

Inheritance PatternsMutationHumansThyroid Hormone Receptors betaThyroid Hormone Resistance SyndromeThyroid Hormone Receptors betaautoimmune thyroid diseaseepigenetic effectresistance to thyroid hormonethyroid dysgenesisthyroid hormone receptorvariant of unknown significance

Identifiers

PMID33868182
PMCPMC8044682
OpenAlexW3139757481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.