ReviewFrontiers in endocrinology2021
The Effects of Non-Nutritive Sweetener Consumption in the Pediatric Populations: What We Know, What We Don't, and What We Need to Learn.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Effects of Nonnutritive Sweeteners on the BMI of Children and Adolescents: A Systematic Review and Meta-Analysis of Randomized Controlled Trials and Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Trial
- Trial
- Age-Related Differences in Knowledge-Attitude-Practice Patterns of Nonnutritive Sweetener Consumption among Adolescents and Adults: A Cross-Sectional Survey in Southeast Nigeria.Current developments in nutrition · 2026Article
- Inflammatory Bowel Disease in Children and Young People Living With Overweight or Obesity: A Critical Narrative Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Review
- Prevalence and Factors Associated with the Use of Artificial Sweeteners in Nonpregnant, Nonlactating Females of Reproductive Age - A Systematic Review.Current developments in nutrition · 2025Article
- Body Recomposition Effects of Long-Term Glycyrrhizin Consumption in Nonobese Individuals: From the Clinic to the Bench.ACS pharmacology & translational science · 2025Article
- Nutritional portrait of processed foods purchased in Québec (Canada), 2016-2022.Public health nutrition · 2025Article
- Urinary excretion of low- and no-calorie sweeteners (LNCS) and associated food sources, as observed in the German cross-sectional KarMeN-study.European journal of nutrition · 2025Article
- Artificial Sweeteners in Food Products: Concentration Analysis, Label Practices, and Cumulative Intake Assessment in Croatia.Nutrients · 2025Article
- Effect of Nutritive and Non-Nutritive Sweeteners on the Lipid Profile, Castelli Index I and II, and Atherogenic Index of Plasma Using Experimental Rat Models.Journal of nutrition and metabolism · 2025Article
- Experts contributions to the development of a non-sugar sweeteners warning label for Brazilian food products.PloS one · 2025Article
- Sucralose-Enhanced Adipogenesis on Preadipocyte Human Cell Line During Differentiation Process.International journal of molecular sciences · 2024Article
- Effects of Sucralose Supplementation on Glycemic Response, Appetite, and Gut Microbiota in Subjects with Overweight or Obesity: A Randomized Crossover Study Protocol.Methods and protocols · 2024Article
- Chronic Use of Artificial Sweeteners: Pros and Cons.Nutrients · 2024Review
- Investigating the Sociodemographic and Health Characteristics of Non-Sugar Sweeteners Consumption in Greek School-Aged Children: A Cross-Sectional Study.Children (Basel, Switzerland) · 2024Article
- Effects of front-of-package caffeine and sweetener disclaimers in Mexico: cross-sectional results from the 2020 International Food Policy Study.Public health nutrition · 2023Article
- Ultra-Processed Food, Reward System and Childhood Obesity.Children (Basel, Switzerland) · 2023Review
- Article
- Maternal consumption and perinatal exposure to non-nutritive sweeteners: should we be concerned?Frontiers in pediatrics · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood obesity is increasing at an alarming rate in the United States. This trend carries serious risk of children developing obesity-related diseases including Type 2 diabetes and cardiovascular disease. Non-nutritive sweeteners (NNS) are used as substitution for table sugar as a way to prevent weight gain. Their consumption is ubiquitous in adults and children; however the long-term health outcomes of chronic NNS consumption in children are unclear. Conflicting observational studies suggest that children consuming NNS are at risk of obesity and development of type 2 diabetes, while others concluded some benefits in weight reduction. Here, we review the physiological mechanisms that can contribute to the negative metabolic effects of NNS. We will focus on how NNS alters the sweet perception leading to increase caloric consumption, how NNs alters the gut microbiota, and how NNS may disrupt glucose homeostasis and initiate a vicious cycle of pancreatic endocrine dysfunction. Studies focused on the pediatric population are limited but necessary to determine whether the potential weight loss benefits outweigh the potential negative metabolic outcomes during this critical development period.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.