ReviewFrontiers in psychiatry2021
Role of DNA Methylation in Mediating Genetic Risk of Psychiatric Disorders.
Review in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Long-Read sequencing in psychiatric omics: a systematic review of current evidence.Molecular psychiatry · 2026Pooled it
- Epigenetic signatures relating to disease-associated genotypic burden in familial risk of bipolar disorder.Translational psychiatry · 2022Pooled it
- Combining DNA methylation features and clinical characteristics predicts ketamine treatment response for PTSD.iScience · 2026Article
- Epigenetic aging in anxiety disorders: diagnostic subtype differences and associations with social functioning.BMC medicine · 2025Article
- Application of microRNA In Situ Hybridization on Long-term Stored Human Formalin-fixed Paraffin-embedded Brain Samples from Psychiatric Patients.Molecular neurobiology · 2025Article
- SLC6A3 gene methylation may be associated with alcohol use disorder, but personality and life stress may not influence methylation.CNS spectrums · 2025Article
- Multi-Omics Mendelian Randomization Identifies a DNA Methylation-ZDHHC20-Immune Axis Associated With Schizophrenia Risk.Brain and behavior · 2025Article
- Article
- SNP-associated differential methylation inEpigenomics · 2025Article
- A multi-omics study of brain tissue transcription and DNA methylation revealing the genetic pathogenesis of ADHD.Briefings in bioinformatics · 2024Article
- Review
- DNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans.Molecular psychiatry · 2024Article
- The Psychoneuroimmunological Model of Moral Distress and Health in Healthcare Workers: Toward Individual and System-Level Solutions.Comprehensive psychoneuroendocrinology · 2024Review
- Combination of 15q24 Microdeletion Syndrome and Metabolic Imbalance in a Patient with Atypical Autism.Journal of molecular neuroscience : MN · 2024Article
- The Potential for Artificial Intelligence Applied to Epigenetics.Mayo Clinic proceedings. Digital health · 2023Article
- Epigenetic and epitranscriptomic regulation of axon regeneration.Molecular psychiatry · 2023Review
- Editorial: Epigenomic contributions to autism spectrum disorders.Frontiers in neuroscience · 2023Article
- Review
- The role of BDNF exon I region methylation in the treatment of depression with sertraline and its clinical diagnostic value.Journal of clinical laboratory analysis · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychiatric disorders are common, complex, and heritable conditions estimated to be the leading cause of disability worldwide. The last decade of research in genomics of psychiatry, performed by multinational, and multicenter collaborative efforts on hundreds of thousands of mental disorder cases and controls, provided invaluable insight into the genetic risk variants of these conditions. With increasing cohort sizes, more risk variants are predicted to be identified in the near future, but there appears to be a knowledge gap in understanding how these variants contribute to the pathophysiology of psychiatric disorders. Majority of the identified common risk single-nucleotide polymorphisms (SNPs) are non-coding but are enriched in regulatory regions of the genome. It is therefore of great interest to study the impact of identified psychiatric disorders' risk SNPs on DNA methylation, the best studied epigenetic modification, playing a pivotal role in the regulation of transcriptomic processes, brain development, and functioning. This work outlines the mechanisms through which risk SNPs can impact DNA methylation levels and provides a summary of current evidence on the role of DNA methylation in mediating the genetic risk of psychiatric disorders.
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Registered trials
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