ArticleInternational journal of biological sciences2021
SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing.
Article in International journal of biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Bone Mineral Density, Bone Biomarkers, and Joints in Acute, Post, and Long COVID-19: A Systematic Review.Viruses · 2024Pooled it
- Article
- Global, regional, and national burden of vertebral fractures among women from 1990 to 2021: a systematic analysis based on the global burden of disease study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- The effects of SARS-CoV-2 on bone homeostasis.Frontiers in endocrinology · 2026Review
- Microrna Expression inMicroRNA (Shariqah, United Arab Emirates) · 2026Article
- Musculoskeletal Complications in COVID-19: Exploring the Role of Key Biomarkers.International journal of molecular sciences · 2025Review
- Progress in research on osteoporosis secondary to SARS-CoV-2 infection.Animal models and experimental medicine · 2025Review
- Lag analysis of the effect of air pollution on orthopedic postoperative infection in Hebei Province and Xinjiang Uygur Autonomous Region.Scientific reports · 2025Article
- Non-union of a Tibial Plafond Fracture in a COVID-Positive Patient: A Case Report.Journal of orthopaedic case reports · 2025Article
- Incidence and Outcomes of Vertebral Compression Fracture Among Patients Infected with COVID-19.Journal of clinical medicine · 2024Article
- Micro-Epigenetic Markers in Viral Genome: SARS-CoV-2 Infection Impact on Host Cell MicroRNA Landscape.Maedica · 2024Article
- Blockade of endothelin receptors mitigates SARS-CoV-2-induced osteoarthritis.Nature microbiology · 2024Article
- The effect of favipiravir on fracture healing.Acta orthopaedica et traumatologica turcica · 2024Article
- Tailored apoptotic vesicles promote bone regeneration by releasing the osteoinductive brake.International journal of oral science · 2024Article
- Mechanistic insights into bone remodelling dysregulation by human viral pathogens.Nature microbiology · 2024Review
- The critical role of toll-like receptor 4 in bone remodeling of osteoporosis: from inflammation recognition to immunity.Frontiers in immunology · 2024Review
- Non-coding RNAs expression in SARS-CoV-2 infection: pathogenesis, clinical significance, and therapeutic targets.Signal transduction and targeted therapy · 2023Review
- Article
- Musculoskeletal involvement: COVID-19 and post COVID 19.Turkish journal of physical medicine and rehabilitation · 2023Review
- The impact of Sars-Cov-2 infection on the wound healing of cervical treatment in patients with squamous intraepithelial lesions: a retrospective cohort study.Frontiers in medicine · 2023Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The angiotensin-converting enzyme 2 (ACE2) receptor has been identified as the cell entry point for SARS-CoV-2. Although ACE2 receptors are present in the bone marrow, the effects of SARS-CoV-2 on the biological activity of bone tissue have not yet been elucidated. In the present study we sought to investigate the impact of SARS-CoV-2 on osteoblastic activity in the context of fracture healing. MicroRNA-4485 (miR-4485), which we found to be upregulated in COVID-19 patients, negatively regulates osteogenic differentiation. We demonstrate this effect both
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.