ArticleSarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG2021
Transbronchial cryobiopsy for diagnosing parenchymal lung diseases: real-life experience from a tertiary referral center.
Article in Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.
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Who cites it
5 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Yield and safety of different biopsy types in interstitial lung disease: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- A systematic review of procedural and sampling techniques for cryobiopsy in interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- The Role of Surgical Lung Biopsy in Diagnosis and Treatment Guidance for Interstitial Lung Diseases: A Single-Center Retrospective Study.Journal of clinical medicine · 2026Article
- The diagnostic contribution of bronchoalveolar lavage to lung cryo-transbronchial biopsy in interstitial lung diseases.BMC pulmonary medicine · 2025Article
- A refined diagnostic approach for interstitial lung disease: efficient and safe transbronchial cryobiopsy using a 1.1-mm cryoprobe.Frontiers in medicine · 2025Article
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Authors and funding
11 authors.
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Abstract
BACKGROUND AND
objectivesTransbronchial cryobiopsy (cryo-TBB) is increasingly being used in the diagnosis of diffuse parenchymal lung diseases (DPLD). Varying diagnostic success and complication rates have been reported. Herein we report our experience with cryo-TBB, focusing on diagnostic yield, factors affecting diagnosis, and safety.
methodsThis retrospective study was conducted in a tertiary referral chest diseases hospital. Data regarding the patients, procedures, complication rates, diagnostic yield, and the final diagnosis made by a multidisciplinary committee at all diagnosis stages were evaluated.
resultsWe recruited 147 patients with suspected DPLD. The definitive diagnosis was made pathologically in 98 of 147 patients (66.6%) and using a multidisciplinary approach in 109 of 147 (74.1%) cases. The number of samples had a significant effect on diagnostic success. Histopathologic diagnostic yield and diagnostic yield with a multidisciplinary committee after a single biopsy were 50%, and histopathological diagnostic yield and diagnostic yield with multidisciplinary committee increased to 71.4% and 85.7%, respectively, with a second biopsy (p = 0.034). The incidence of mild-to-moderate hemorrhage was 31.9%; no severe hemorrhage occurred. Pneumothorax rate was 15.6%, and the mortality rate was 0.68%.
conclusionsCryo-TBB has sufficient diagnostic yield in the context of a multidisciplinary diagnosis with acceptable complication rates. Performing at least 2 biopsies and from at least 2 segments increases diagnostic success.
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