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ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2021

Low Dose Iron Therapy in Children with Iron Deficiency: DNA Damage and Oxidant Stress Markers.

Hanan M Hamed, Ayat A Motawie, Amany M Abd Al-Aziz, Gamila S M El-Saeed, Maha El Wasseif, Abbass A Mourad, Hassan M Salama, Eman Mahmoud Hassan, Neveen A Helmy, Eman Elghoroury

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In one paragraph

Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Hanan M HamedPediatrics Department, National Research Centre, Cairo, Egypt.
Ayat A MotawiePediatrics Department, National Research Centre, Cairo, Egypt.
Amany M Abd Al-AzizPediatrics Department, National Research Centre, Cairo, Egypt.
Gamila S M El-SaeedMedical Biochemistry Department, National Research Centre, Cairo, Egypt.
Maha El WasseifMedical Biochemistry Department, National Research Centre, Cairo, Egypt.
Abbass A MouradPediatrics Department, National Research Centre, Cairo, Egypt.
Hassan M SalamaPediatrics Department, National Research Centre, Cairo, Egypt.
Eman Mahmoud HassanClinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Neveen A HelmyClinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
Eman ElghorouryClinical and Chemical Pathology Department, National Research Centre, Cairo, Egypt.
National Research Centre · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conflicting data are available regarding oral iron therapy in iron deficiency (ID), iron deficiency anemia (IDA) and its relation to DNA damage, oxidative stress and antioxidant markers. Our aim was assessment of DNA damage, oxidative stress and anti-oxidant markers in children with ID and IDA before and after low dose iron therapy. The study was conducted in two stages, first stage was assessment of DNA damage using comet assay, malondialdehyde (MDA) and anti-oxidant enzymes levels (superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) & total antioxidant capacity (TAC) in thirty-nine children with IDA, forty-five children with ID without anemia and sixty healthy controls. Second stage was assessment of previous markers together with hematological response following oral therapy with 10 mg/day ferric ammonium citrate for 8 weeks. Before treatment, there was no significant difference between the three groups regarding MDA, GPx, SOD, CAT and TAC. A significant increase was detected in the DNA damage in the 2 groups compared to control (

Indexed as

Comet assayDNA damageIron deficiency anemiaOxidant and antioxidant stress

Identifiers

PMID33867736
PMCPMC8012429
OpenAlexW3080168416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.