ArticleSensors and actuators. B, Chemical1999
Potassium and sodium measurements at clinical concentrations using phase-modulation fluorometry.
Article in Sensors and actuators. B, Chemical, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 43 citations in OpenAlex.
- Potassium Disorders in Pet Rabbits and Their Association with Glycemia, Azotemia, and Clinical Outcome.Animals : an open access journal from MDPI · 2026Article
- Fluorescence depolarization dynamics of ionic strength sensors using time-resolved anisotropy.Biophysical journal · 2021Article
- A highly selective mitochondria-targeting fluorescent K(+) sensor.Angewandte Chemie (International ed. in English) · 2015Article
- Polymer-free optode nanosensors for dynamic, reversible, and ratiometric sodium imaging in the physiological range.Scientific reports · 2013Article
- Enzyme fluorescence as a sensing tool: new perspectives in biotechnology.Current opinion in biotechnology · 2001Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We describe the possibility of measuring sodium and potassium at the concentrations present in whole blood using lifetime-based sensing and phase-modulation fluorometry. The probe SBFO was shown to display changes in phase or modulation at sodium concentrations near 100 mM, and to be mostly independent of interfering effects due to potassium. The probe CD222 was found unsuitable for measurements of potassium in blood using intensity-ratio measurements, due to similar spectral changes induced by sodium. However, sodium at blood concentrations near 100 mM causes only a minor change in the lifetime of CD222. Hence, CD222 and lifetime-based sensing can be used to measure blood levels of potassium in the presence of 130 mM sodium. Similarly, sodium causes only a modest change in the lifetime of the potassium probe PBFI, which displays potassium-dependent lifetimes. For both CD222 and PBFI, the presence of blood levels of sodium increases the apparent potassium dissociation constants into the blood physiological range. In total, these results demonstrated the possibility of lifetime-based sensing of sodium and potassium at the extracellular cation concentrations present in blood or blood serum.
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Registered trials
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