ArticleMedical journal, Armed Forces India2021
Hepatitis B vaccination in Indian children: Seroprotection and age-related change in antibody titres.
Article in Medical journal, Armed Forces India, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Immunogenicity and Safety of Biological E's Monovalent rDNA Hepatitis B Vaccine (BEVACViruses · 2026Trial
- Less than Half of Pediatric Cancer Survivors have Protective Titres of Anti-HBs Antibodies.Indian journal of pediatrics · 2026Article
- Proportion of hepatitis B virus infection, vaccine awareness, and coverage among pregnant mothers attending a tertiary care hospital in Odisha - A cross-sectional study.Journal of family medicine and primary care · 2025Article
- Assessing Hepatitis B virus infection, risk factors and immunization among particularly vulnerable tribal groups in Eastern India.Scientific reports · 2025Article
- Immune response and associated factors to Hepatitis B vaccination among children under five attending care at mulago hospital.BMC pediatrics · 2025Article
- Hepatitis B vaccination coverage rates among under-five children in India: a systematic review and meta-analysis protocol.Frontiers in pediatrics · 2025Article
- Seroconversion among children with HBsAg-positive mothers in Indonesia and factors affecting the anti-HBs titers.Global epidemiology · 2024Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChildhood immunization against hepatitis B is one of the most effective strategies for reducing the global burden of chronic hepatitis B infection and its sequelae. There are limited data from India on both the anti-Hep B antibody titres in children after vaccination and the age-related decline in the titres. This study was planned to estimate the proportion of children in the age group of 1-10 years who develop protective levels of anti-hepatitis B antibodies after childhood vaccination and to examine the change in antibody titres with age in these children.
methodsA hospital-based cross-sectional study was carried out in children admitted to the hospital for various ailments. Basic demographic data, vaccination history and HBsAg status of the mother were recorded. All the enrolled children were evaluated for HBsAg and anti hepatitis B surface antibody (anti-HBS) titres. Institutional ethical clearance was obtained, and informed consent from the parents of the children was taken before drawing samples.
resultsWe found that 68.86% Confidence Interval ((CI): 59.8-76.8%) of the children showed protective antibody titres after vaccination, while 31.14% (CI: 23.1-40.2%) of the children had titres less than 10 IU/L. Although 100% of children in the age group from birth to three years had titres more than 10 IU/L, this percentage showed a decline across the age groups, and 60% of children aged 9-10 years had titres less than 10 IU/L.
conclusionChildhood vaccination against hepatitis B is effective in 68% children, and the antibody levels showed a steady decline with increasing age.
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