ArticleJournal of Alzheimer's disease : JAD2021
Cortical Thickness, Volume, and Surface Area in the Motoric Cognitive Risk Syndrome.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Motoric Cognitive Risk Syndrome and the Risk of Incident Dementia: A Systematic Review and Meta-Analysis of Cohort Studies.Gerontology · 2024Pooled it
- Gait in cerebral small vessel disease, pre-dementia, and dementia: A systematic review.International journal of stroke : official journal of the International Stroke Society · 2023Pooled it
- Beyond gait speed: a multidimensional motor signature of motoric cognitive risk syndrome identified through domain-specific anomaly detection.GeroScience · 2026Article
- Estimating the fraction of variance of crystallized intelligence explained by cortical surface area in early adolescence.bioRxiv : the preprint server for biology · 2026Article
- Vitamin D, systemic inflammation, and motoric cognitive risk: exploring the risk factors and mediation pathways.Frontiers in aging · 2026Article
- Worse visibility of deep medullary veins is associated with larger lateral ventricles but not with cortical thickness.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026Article
- Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19.Nature communications · 2025Article
- Sex-specific brain atrophy patterns associated with the motoric cognitive risk syndrome.Journal of Alzheimer's disease : JAD · 2025Article
- Gait, balance, and physical performance as markers of early Alzheimer's disease and related dementia risk.Journal of Alzheimer's disease : JAD · 2025Article
- Clinical, biological, and neuroimaging profiles for motoric cognitive risk syndrome in older adults: The MIND-China study.Journal of internal medicine · 2025Article
- Evaluation criteria for diagnosing motoric cognitive risk syndrome: a scoping review.Dementia & neuropsychologia · 2025Review
- Association between Motoric Cognitive Risk Syndrome and Indicators of Reflecting Independent Living among Community-Dwelling Older Adults in Japan: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Elevated Blood Homocysteine Increases the Risk of Incident Motoric Cognitive Risk Syndrome: A Two-Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- Correlation between frailty and reduction in cortical thickness in patients with chronic obstructive pulmonary disease.Scientific reports · 2024Article
- Distinct Patterns of Brain Atrophy in Amnestic Mild Cognitive Impairment and Motoric Cognitive Risk Syndromes.Neuro-degenerative diseases · 2024Article
- Exploring shared neural substrates underlying cognition and gait variability in adults without dementia.Alzheimer's research & therapy · 2023Article
- Dual cognitive and mobility impairments and future dementia - Setting a research agenda.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Prevalence and predictors of Motoric Cognitive Risk syndrome in a community-dwelling older Scottish population: A longitudinal observational study.International journal of geriatric psychiatry · 2022Observational
- Motoric Cognitive Risk Syndrome: Prevalence and Cognitive Performance. A cross-sectional study.Lancet regional health. Americas · 2022Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 5 countries.
Funding
Abstract
backgroundThe motoric cognitive risk (MCR) syndrome is a pre-clinical stage of dementia characterized by slow gait and cognitive complaint. Yet, the brain substrates of MCR are not well established.
objectiveTo examine cortical thickness, volume, and surface area associated with MCR in the MCR-Neuroimaging Consortium, which harmonizes image processing/analysis of multiple cohorts.
methodsTwo-hundred MRIs (M age 72.62 years; 47.74%female; 33.17%MCR) from four different cohorts (50 each) were first processed with FreeSurfer 6.0, and then analyzed using multivariate and univariate general linear models with 1,000 bootstrapped samples (n-1; with resampling). All models adjusted for age, sex, education, white matter lesions, total intracranial volume, and study site.
resultsOverall, cortical thickness was lower in individuals with MCR than in those without MCR. There was a trend in the same direction for cortical volume (p = 0.051). Regional cortical thickness was also lower among individuals with MCR than individuals without MCR in prefrontal, insular, temporal, and parietal regions.
conclusionCortical atrophy in MCR is pervasive, and include regions previously associated with human locomotion, but also social, cognitive, affective, and motor functions. Cortical atrophy in MCR is easier to detect in cortical thickness than volume and surface area because thickness is more affected by healthy and pathological aging.
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Registered trials
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