Evidence map›Paper›PMID 33867211›Full record

ArticleAmerican journal of preventive medicine2021

Physical Activity and Hypertension From Young Adulthood to Middle Age.

Jason M Nagata, Eric Vittinghoff, Kelley Pettee Gabriel, Andrea K Garber, Andrew E Moran, Stephen Sidney, Jamal S Rana, Jared P Reis, Kirsten Bibbins-Domingo

Open access · greenAbstract read
In one paragraph

Article in American journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Social epidemiology of cardiometabolic risk factors in early adolescents.International journal of cardiology. Cardiovascular risk and prevention · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Physical activity and the risk of developing 8 age-related diseases: epidemiological and Mendelian randomization studies.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. The necessity of improving cardiovascular health in commercial motor vehicle drivers.American heart journal plus : cardiology research and practice · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Prevalence of Tobacco and Alcohol Consumption and its Association with Incident Hypertension among Young Adults Residing in an Urban Area of West Bengal.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Jason M NagataDivision of Adolescent & Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, California. Electronic address: jasonmnagata@gmail.com.
Eric VittinghoffDepartment of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California.
Kelley Pettee GabrielDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama.
Andrea K GarberDivision of Adolescent & Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, San Francisco, California.
Andrew E MoranDivision of General Medicine, Columbia University, New York, New York.
Stephen SidneyDivision of Research, Kaiser Permanente Northern California, Oakland, California.
Jamal S RanaDivision of Research, Kaiser Permanente Northern California, Oakland, California; Division of Cardiology, Kaiser Permanente Northern California, Oakland, California.
Jared P ReisDivision of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, Bethesda, Maryland.
Kirsten Bibbins-DomingoDepartment of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California.
University of California, San Francisco · USKaiser Permanente · USColumbia University · USNational Heart Lung and Blood Institute · USUniversity of Alabama at Birmingham · US

Funding

Hypertension Management in Minority and Low-income PopulationsK24DK103992 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIBBINS-DOMINGO, KIRSTEN · 2014 to 2018
$917k
Informing national guidelines on adolescent and young adult physical activity and sedentary behavior to prevent cardiovascular diseaseK08HL159350 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI NAGATA, JASON M · 2021 to 2025
$869k
NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007INHLBI NIH HHS K08 HL159350NIDDK NIH HHS K24 DK103992
6 · The paper itself

Abstract

introductionThe optimum physical activity dose to achieve during young adulthood to prevent hypertension using the 2017 American College of Cardiology/American Heart Association guidelines remains undefined. This study aims to determine the association between level and change in physical activity through the adult life course and the onset of hypertension using these 2017 definitions.

methodsIn 2020, prospective community-based cohort data of 5,115 Coronary Artery Risk Development in Young Adults study participants were analyzed. The cohort included Black and White men and women aged 18-30 years at baseline (1985-1986) at 4 urban sites, collected through 30 years of follow-up (2015-2016). Individualized physical activity trajectories were developed for each participant using linear mixed models.

resultsBlack women reported the lowest physical activity levels from young adulthood through middle age. Lower physical activity score (per 100 units) at age 18 years was associated with 4% (95% CI=1%, 7%, p=0.002) higher odds of hypertension incidence. Each additional 1-unit reduction per year in physical activity score was associated with 2% (95% CI=1%, 3%, p=0.001) higher annual odds of hypertension incidence. Meeting approximately the current minimum physical activity guideline levels at age 18 years and through follow-up was not protective of hypertension incidence; however, meeting approximately twice the current minimum physical activity guideline level at age 18 years and through follow-up was protective of hypertension incidence.

conclusionsModerate physical activity levels may need to exceed current minimum guidelines to prevent hypertension onset using 2017 American College of Cardiology/American Heart Association definitions.

Indexed as

HypertensionAdolescentAdultAmerican Heart AssociationExerciseFemaleHumansMaleMiddle AgedProspective StudiesRisk FactorsUnited StatesYoung Adult

Identifiers

PMID33867211
PMCPMC8494495
OpenAlexW3155087565

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.