ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2021
Risk of Symptomatic Kidney Stones During and After Pregnancy.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 27 citations in OpenAlex.
- Labor and Delivery Complications in Women With Renal Calculi: Increased Risk and Prolonged Hospital Stay.Cureus · 2026Article
- Preeclampsia and Onset of Renal Disorders in the Long-Term Period following Pregnancy.American journal of nephrology · 2026Article
- Use of Vitamins and Supplements During Pregnancy and Their Association with Maternal and Birth Outcomes: A Prospective Cohort Study.Patient preference and adherence · 2026Article
- Development of tonsil stones during pregnancy.Obstetric medicine · 2025Article
- The role of pharmacological interventions in managing urological complications during pregnancy and childbirth: A review.Medicine · 2025Review
- Maternal-Fetal Complications in Renal Colic during Pregnancy: A Scoping Review.Journal of clinical medicine · 2024Article
- Urinary Oxalate Excretion During Pregnancy in Primary Hyperoxaluria Type 1: A Report of 4 Cases.Kidney medicine · 2024Article
- Review
- Ureteroscopic lithotripsy of ureteric stone using thulium fiber laser in a pregnant patient, case report.Urology case reports · 2023Article
- A comparison of adverse pregnancy events between ureteral stents and percutaneous nephrostomy tubes in the treatment of nephrolithiasis during pregnancy: A propensity score-matched analysis of a large multi-institutional research network.World journal of urology · 2023Article
- The interplay between bacterial biofilms, encrustation, and wall shear stress in ureteral stents: a review across scales.Frontiers in urology · 2023Review
- In focus: perplexing increase of urinary stone disease in children, adolescent and young adult women and its economic impact.Frontiers in medicine · 2023Article
- Subcutaneous Infusion of rhPTHJournal of the Endocrine Society · 2022Article
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10 authors at 2 institutions in 1 country.
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Abstract
RATIONALE &
objectiveThere are several well-known anatomical and physiological changes during pregnancy that could contribute to kidney stone formation, but evidence that they increase the risk of kidney stones during pregnancy is lacking. We determined whether there was an increased risk of a first-time symptomatic kidney stone during and after pregnancy. STUDY
designA population-based matched case-control study. SETTING &
participants945 female first-time symptomatic kidney stone formers aged 15-45 years and 1,890 age-matched female controls in Olmsted County, MN, from 1984-2012. The index date was the date of onset of a symptomatic kidney stone for both the case and her matched controls. EXPOSURE: The primary exposure was pregnancy with assessment for variation in risk across different time intervals before, during, and after pregnancy. Medical records were manually reviewed to determine the conception and delivery dates for pregnancies. OUTCOME: Medical record-validated first-time symptomatic kidney stone. ANALYTICAL APPROACH: Conditional and unconditional multivariable logistic regression analysis.
resultsCompared with nonpregnant women, the odds of a symptomatic kidney stone forming in women was similar in the first trimester (OR, 0.92; P=0.8), began to increase during the second trimester (OR, 2.00; P=0.007), further increased during the third trimester (OR, 2.69; P=0.001), peaked at 0 to 3 months after delivery (OR, 3.53; P<0.001), and returned to baseline by 1year after delivery. These associations persisted after adjustment for age and race or for diabetes mellitus, hypertension, and obesity. These results did not significantly differ by age, race, time period, or number of prior pregnancies. Having a prior pregnancy (delivery date>1year ago) was also associated with a first-time symptomatic kidney stone (OR, 1.27; P=0.01). LIMITATIONS: Observational study design in a predominantly White population. The exact timing of stone formation cannot be determined.
conclusionsPregnancy increases the risk of a first-time symptomatic kidney stone. This risk peaks close to delivery and then improves by 1 year after delivery, though a modest risk of a kidney stone still exists beyond 1 year after delivery.
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