Evidence map›Paper›PMID 33866836›Full record

ArticleThe Journal of international medical research2021

Identification of predictors of the ovarian response to clomiphene citrate in infertile women with polycystic ovary syndrome: a prospective cohort study.

Hexia Xia, Xiaoli Sun, Haiyun Guan, Ruixiu Zhang, Wei Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hexia XiaDepartment of Reproductive Endocrinology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China.
Xiaoli SunAffiliated Hospital of Nantong University, Nantong, China.
Haiyun GuanDepartment of Reproductive Endocrinology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China.
Ruixiu ZhangDepartment of Gynaecology, Shanghai First Maternity and Infant Hospital, Tongji University, Shanghai, China.
Wei ZhangDepartment of Reproductive Endocrinology, Obstetrics and Gynaecology Hospital, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-7187-108X
State Key Laboratory of Oncogene and Related Genes · CNNantong University · CNShanghai First Maternity and Infant Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo identify predictors of the ovarian response to clomiphene citrate (CC) in infertile patients with polycystic ovary syndrome (PCOS).

methodsWe performed a prospective cohort study of infertile patients with PCOS. The participants underwent assessments of their physical, endocrine, and metabolic characteristics, and treatment with CC at an initial dose of 50 mg/day and a maximum of 100 mg/day between days 3 and 7 of their menstrual cycles. Participants who ovulated were identified as responders and those who did not as non-responders.

resultsOf the 72 participants, 48 (66.7%) were identified as responders and 24 as non-responders. Sex hormone-binding globulin (SHBG) (odds ratio 1.022, 95% confidence interval: 1.000-1.045) was found to be associated with the ovarian response to CC using logistic multivariate regression analysis. Receiver operating characteristic analysis also showed that SHBG was a significant predictor of the response to CC (area under the curve 0.799).

conclusionWe have shown that SHBG is the best prognostic indicator of an ovulatory response to CC. However, larger prospective studies, in which more variables are assessed, are required to confirm this finding and to identify appropriate cut-off values.

Indexed as

AdultChinaClomipheneCohort StudiesFemaleFertility Agents, FemaleHumansInfertility, FemaleOvulation InductionPolycystic Ovary SyndromeProspective StudiesROC CurveTreatment OutcomeClomipheneFertility Agents, Femaleclomiphene citratefree androgen indexPolycystic ovary syndromepredictorprognosisreceiver operating characteristic curvesex hormone-binding globulin

Identifiers

PMID33866836
PMCPMC8753794
OpenAlexW3154240966

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.