Evidence map›Paper›PMID 33866806›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2021

Protein aggregation and the evolution of stress resistance in clinical yeast.

Yiwen R Chen, Inbal Ziv, Kavya Swaminathan, Joshua E Elias, Daniel F Jarosz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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  6. Review
  7. How does epigenetics influence the course of evolution?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yiwen R ChenDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Inbal ZivDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Kavya SwaminathanDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Joshua E EliasDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Daniel F JaroszDepartment of Chemical and Systems Biology, Stanford University, Stanford, CA 94305, USA.
Stanford University · US

Funding

Discovery of protein aggregates during vertebrate aging and neurodegenerationRF1AG057334 · NIA · STANFORD UNIVERSITY · PI BRUNET, ANNE, JAROSZ, DANIEL · 2017 to 2017
$3.7M
Protein-based Molecular Memories in Gene Regulation, Disease, and DevelopmentDP2GM119140 · NIGMS · STANFORD UNIVERSITY · PI JAROSZ, DANIEL · 2015 to 2015
$2.4M
NIA NIH HHS RF1 AG057334NIGMS NIH HHS DP2 GM119140
6 · The paper itself

Abstract

Protein aggregation, particularly in its prion-like form, has long been thought to be detrimental. However, recent studies have identified multiple instances where protein aggregation is important for normal physiological functions. Combining mass spectrometry and cell biological approaches, we developed a strategy for the identification of protein aggregates in cell lysates. We used this approach to characterize prion-based traits in pathogenic strains of the yeast

Indexed as

Evolution, MolecularCell Cycle ProteinsNuclear ProteinsPeptide Elongation FactorsPrionsProtein AggregatesPyruvate KinaseRibonucleoproteins, Small NucleolarSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsStress, PhysiologicalCdc19 protein, S cerevisiaeCell Cycle ProteinsNOP1 protein, S cerevisiaeNuclear ProteinsPeptide Elongation FactorsPrionsProtein AggregatesPyruvate KinaseRibonucleoproteins, Small NucleolarSaccharomyces cerevisiae ProteinsYEF3 protein, S cerevisiaeaggregatechaperonedrug resistanceevolutionprion

Identifiers

PMID33866806
PMCPMC8059508
OpenAlexW3155564940

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.