Evidence map›Paper›PMID 33866519›Full record

ArticleIrish journal of medical science2021

Postauricular injection of methylprednisolone sodium succinate as a salvage treatment for refractory sudden sensorineural hearing loss.

Gang Ren, Jue Xu, Longjiang Lan, Bingliang Ma, Qi Zhang

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Article in Irish journal of medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Gang RenDepartment of Otolaryngology, the First Affiliated Hospital of Huzhou University, the First People's Hospital of Huzhou, Huzhou, 313000, Zhejiang, China.ORCID http://orcid.org/0000-0003-4082-1025
Jue XuDepartment of Otolaryngology, the First Affiliated Hospital of Huzhou University, the First People's Hospital of Huzhou, Huzhou, 313000, Zhejiang, China.
Longjiang LanDepartment of Otolaryngology, the First Affiliated Hospital of Huzhou University, the First People's Hospital of Huzhou, Huzhou, 313000, Zhejiang, China.
Bingliang MaDepartment of Otolaryngology, the First Affiliated Hospital of Huzhou University, the First People's Hospital of Huzhou, Huzhou, 313000, Zhejiang, China.
Qi ZhangDepartment of Otolaryngology, the First Affiliated Hospital of Huzhou University, the First People's Hospital of Huzhou, Huzhou, 313000, Zhejiang, China. 383587773@qq.com.
Huzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostauricular steroid administration has been popular for treating sudden sensorineural hearing loss. However, there are few reports on its use in patients with refractory sudden sensorineural hearing loss (RSSNHL).

aimsThe objective of this study was to investigate the therapeutic efficacy of postauricular steroid injection as a salvage treatment for RSSNHL patients.

methodsThis retrospective study enrolled 63 RSSNHL patients between January 2016 and January 2019. Thirty-three patients of them who have been divided into the treatment group received postauricular methylprednisolone sodium succinate injection. The remaining 30 patients who formed the control group did not receive any steroid as a salvage therapy. Improvements in hearing were evaluated between pre-salvage therapy and 3 months follow-up after salvage therapy.

resultsThe median hearing gain in PTA was 9.88 dB HL (quartile range 7.58, 18.65) in the treatment group and 0.90 dB HL (quartile range 0.00, 4.90) in the control group (P<0.01). According to the criteria of Furuhashi, the total percentage for effective prognosis was 48.48% (16/33) in the treatment group and 10.00% (3/30) in the control group (P<0.01). The time interval from onset to study entry was significantly and independently associated with the prognosis for RSSNHL patients (P< 0.01).

conclusionsThe present findings suggest that postauricular corticosteroid administration as a salvage treatment demonstrated better results than no treatment for RSSNHL patients. The time interval from onset to study entry was mainly the prognostic factor for RSSNHL patients. It is therefore considered that postauricular corticosteroid administration may be used as a salvage therapy for RSSNHL patients.

Indexed as

Hearing Loss, SensorineuralMethylprednisolone HemisuccinateDexamethasoneGlucocorticoidsHumansMethylprednisoloneRetrospective StudiesSalvage TherapyTreatment OutcomeDexamethasoneGlucocorticoidsMethylprednisoloneMethylprednisolone HemisuccinateMethylprednisolone sodium succinatePostauricular injectionRefractory sudden sensorineural hearing loss (RSSNHL)Salvage treatment

Identifiers

PMID33866519
OpenAlexW3156133247

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.