Evidence map›Paper›PMID 33866422›Full record

ArticleEuropean journal of nutrition2021

Broccoli microgreens juice reduces body weight by enhancing insulin sensitivity and modulating gut microbiota in high-fat diet-induced C57BL/6J obese mice.

Xiangfei Li, Shuhua Tian, Yunfan Wang, Jie Liu, Jing Wang, Yingjian Lu

Abstract read
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In one paragraph

Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
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  7. Review
  8. Article
  9. Biofortification of Broccoli Microgreens (Foods (Basel, Switzerland) · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Current research in food science · 2023
    Review
  14. Review
  15. Beneficial Effects of Broccoli (In vivo (Athens, Greece)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Xiangfei LiCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, People's Republic of China.
Shuhua TianCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, People's Republic of China.
Yunfan WangCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, People's Republic of China.
Jie LiuChina-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology and Business University, Beijing, 100048, China.
Jing WangChina-Canada Joint Lab of Food Nutrition and Health (Beijing), Beijing Technology and Business University, Beijing, 100048, China.
Yingjian LuCollege of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, 210023, People's Republic of China. yingjianlu@nufe.edu.cn.ORCID http://orcid.org/0000-0001-6425-2774
Nanjing University of Finance and Economics · CNBeijing Technology and Business University · CNNanjing Agricultural University · CN

Funding

China Postdoctoral Science Foundation funded project 2020M671517Natural Science Foundation of Jiangsu Province SBK2018042932Open project of China Canada food nutrition and health Joint Laboratory ZJ-2020-07Postgraduate Research & Practice Innovation Program of Jiangsu Province KYCX19_1422the National Natural Science Foundation of China No. 31801545
6 · The paper itself

Abstract

purposeThis study aimed to explore the protective effect of broccoli microgreens juice (BMJ) during C57BL/6J mice obesity development.

methodsThe obese model mice, induced by feeding high-fat diet (HFD), were treated with BMJ by gavage for 10 weeks. Melbine was gavaged at 300 mg/(kg bw)/d, as a positive control group.

resultsBMJ supplementation significantly reduced white adipose tissues (WAT) mass, the body weight and adipocyte size, and increased water intake in HFD-fed mice. Moreover, it improved glucose tolerance, reduced insulin level and HOMA-IR value, and alleviated insulin resistance. Compared with the HFD group, BMJ supplementation significantly increased the relative abundance of Bacteroidetes and decreased the ratio of Firmicutes to Bacteroidetes at the phylum level, and enriched Bacteroides_acidifaciens at the species level. These changes in the composition of gut microbiota are associated with the production of short-chain fatty acids (SCFAs), and reduced LPS levels, and had an obvious anti-inflammatory effect.

conclusionsThese findings suggested that the protective effects of BMJ on diet-induced obesity may be involved in gut microbiota-SCFAs-LPS-inflammatory axis. In addition, BMJ can enhance liver antioxidant capacity and reduce liver fat accumulation. Consequently, these results sustain BMJ as a novel functional food for obesity, on the basis of its opposing effects on HFD-induced obesity in mice.

Indexed as

BrassicaGastrointestinal MicrobiomeInsulin ResistanceAnimalsDiet, High-FatMiceMice, Inbred C57BLMice, ObeseObesityAdipocyteInsulin sensitivityObesityOxidative stressShort-chain fatty acids

Identifiers

PMID33866422
OpenAlexW3153650755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.