ArticleEuropean radiology2021
MRI features of symptomatic amputation neuromas.
Article in European radiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Postoperative Imaging Characteristics of Targeted Muscle Reinnervation and Regenerative Peripheral Nerve Interfaces.Plastic and reconstructive surgery. Global open · 2026Article
- Magnetic resonance imaging appearance of targeted muscle reinnervation and regenerative peripheral nerve interfaces in oncologic amputees.Skeletal radiology · 2026Article
- Postoperative Imaging of Bone and Soft Tissue Tumors in the Extremity: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2024Review
- Traumatic neuromas with hemangiomas of diverse morphology in the left upper arm: a case description.Quantitative imaging in medicine and surgery · 2024Article
- The Peripheral Nerve Surgeon's Role in the Management of Neuropathic Pain.Plastic and reconstructive surgery. Global open · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
objectivesTo demonstrate the magnetic resonance imaging (MRI) features of amputation neuromas in lower extremity amputees and investigate independent predictive MRI features for symptomatic neuromas.
methodsThis retrospective study included 45 amputation neuromas in 44 lower extremity amputees. Two radiologists assessed the imaging features, including shape, size, type (end-bulb or spindle), signal intensity (SI), heterogeneity, margins, enlarged fascicles, dark outer rim, tail sign, target sign, enhancement, perilesional fibrosis, and muscle denervation. The neuromas were categorized into symptomatic (n = 24) or asymptomatic (n = 21). Symptomatic neuromas were determined based on neuropathic pain characteristics, the presence of Tinel's sign or tenderness, and response to local anesthetic injection. Univariate and multivariate analyses were performed to identify independent predictive MRI features.
resultsOf 45 neuromas, 80% (36/45) were end-bulb neuromas and 20% (9/45) were spindle-type neuromas. Eighty percent of the neuromas (36/45) were heterogeneous on T2-weighted images (WIs). Enlarged fascicles were present in 42% (19/45) and dark outer rims in 27% (12/45) of the neuromas. Among the 23 neuromas with enhanced images, 78% (18/23) showed enhancement. Heterogeneity on T2-WIs and enhancement ratios were significantly different between the asymptomatic and symptomatic neuroma groups (p < 0.05). The multivariate analyses indicated that heterogeneity on T2-WIs was an independent factor associated with symptomatic neuromas (p < 0.001).
conclusionsHeterogeneity on T2-WIs could be a predictive indicator for symptomatic neuromas in lower extremity amputees. KEY POINTS: • Amputation neuromas are classified as either end-bulb or spindle-type. They can show enlarged fascicles, dark outer rims, and enhancement. • Heterogeneity on T2-weighted images could be a predictive indicator for symptomatic neuromas. • Predicting the symptomatic neuroma on MRI would help in effective management of stump pain.
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