Evidence map›Paper›PMID 33866373›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2021

Altered Thalamocortical Connectivity in 6-Week-Old Infants at High Familial Risk for Autism Spectrum Disorder.

Aarti Nair, Rhideeta Jalal, Janelle Liu, Tawny Tsang, Nicole M McDonald, Lisa Jackson, Carolyn Ponting, Shafali S Jeste, Susan Y Bookheimer, Mirella Dapretto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Aarti NairDepartment of Psychology, School of Behavioral Health, Loma Linda University, Loma Linda, CA 92354, USA.
Rhideeta JalalDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Janelle LiuInterdepartmental Neuroscience Program, University of California, Los Angeles, CA 90095, USA.
Tawny TsangDepartment of Psychology, University of California, Los Angeles, CA 90095, USA.
Nicole M McDonaldDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Lisa JacksonDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Carolyn PontingDepartment of Psychology, University of California, Los Angeles, CA 90095, USA.
Shafali S JesteDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Susan Y BookheimerDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
Mirella DaprettoDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USLoma Linda University · US

Funding

Understanding Repetitive Behavior in AutismP50HD055784 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GESCHWIND, DANIEL H · 2007 to 2021
$32.0M
AN INFORMATICS FACILITY FOR NEUROIMAGINGC06RR015431 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TOGA, ARTHUR W · 2000 to 2000
$2.0M
High Capacity Storage System for Computational BiologyS10OD011939 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WOODS, ROGER P · 2012 to 2012
$598k
EXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR012169 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAZZIOTTA, JOHN C · 1996 to 1997
–
Autism Science Foundation Postdoctoral Fellowship 16-004Brain Mapping Medical Research OrganizationBrain Mapping Support FoundationCapital Group Companies Charitable FoundationNCRR NIH HHS C06 RR012169NCRR NIH HHS C06 RR015431NICHD NIH HHS P50 HD055784NIH HHS S10 OD011939Northstar FundPierson-Lovelace FoundationThe Ahmanson FoundationWilliam M. and Linda R. Dietel Philanthropic Fund
6 · The paper itself

Abstract

Converging evidence from neuroimaging studies has revealed altered connectivity in cortical-subcortical networks in youth and adults with autism spectrum disorder (ASD). Comparatively little is known about the development of cortical-subcortical connectivity in infancy, before the emergence of overt ASD symptomatology. Here, we examined early functional and structural connectivity of thalamocortical networks in infants at high familial risk for ASD (HR) and low-risk controls (LR). Resting-state functional connectivity and diffusion tensor imaging data were acquired in 52 6-week-old infants. Functional connectivity was examined between 6 cortical seeds-prefrontal, motor, somatosensory, temporal, parietal, and occipital regions-and bilateral thalamus. We found significant thalamic-prefrontal underconnectivity, as well as thalamic-occipital and thalamic-motor overconnectivity in HR infants, relative to LR infants. Subsequent structural connectivity analyses also revealed atypical white matter integrity in thalamic-occipital tracts in HR infants, compared with LR infants. Notably, aberrant connectivity indices at 6 weeks predicted atypical social development between 9 and 36 months of age, as assessed with eye-tracking and diagnostic measures. These findings indicate that thalamocortical connectivity is disrupted at both the functional and structural level in HR infants as early as 6 weeks of age, providing a possible early marker of risk for ASD.

Indexed as

Autism Spectrum DisorderBiomarkersCerebral CortexChild Behavior DisordersChild, PreschoolDiffusion Tensor ImagingFemaleGenetic Predisposition to DiseaseHumansInfantInfant, NewbornMaleNeural PathwaysPsychomotor PerformanceRisk AssessmentSocial BehaviorBiomarkersASDfunctional connectivityhigh-risk infantsstructural connectivitythalamus

Identifiers

PMID33866373
PMCPMC8328203
OpenAlexW3152687432

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.