Evidence map›Paper›PMID 33866309›Full record

ArticleCancer prevention research (Philadelphia, Pa.)2021

Comprehensive Analysis of Multiple Cohort Datasets Deciphers the Utility of Germline Single-Nucleotide Polymorphisms in Prostate Cancer Diagnosis.

Wensheng Zhang, Yan Dong, Oliver Sartor, Kun Zhang

Open access · hybridAbstract readValidation Study
In one paragraph

Article in Cancer prevention research (Philadelphia, Pa.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Wensheng ZhangBioinformatics Core of Xavier NIH RCMI Center of Cancer Research, Xavier University of Louisiana, New Orleans, LA 70125, USA.
Yan DongDepartment of Structural and Cellular Biology, Tulane University School of Medicine, New Orleans, LA 70112, USA.ORCID 0000-0003-1622-5354
Oliver SartorDepartment of Medicine, Tulane University School of Medicine, Tulane Cancer Center, New Orleans, LA 70112, USA.ORCID 0000-0002-8777-7343
Kun ZhangBioinformatics Core of Xavier NIH RCMI Center of Cancer Research, Xavier University of Louisiana, New Orleans, LA 70125, USA. kzhang@xula.edu.
Tulane University · USXavier University of Louisiana · US

Funding

STABILITY' (symptomatic review during biologic therapy) Review in Inflammatory Bowel DiseaseP20GM103424 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Seetharama D Jois · 2012 to 2026
$57.4M
Xavier RCMI Renewal Application-Research Infrastructure CoreU54MD007595 · NIMHD · XAVIER UNIVERSITY OF LOUISIANA · PI Thomas Wiese · 2019 to 2026
$41.9M
Trans-omics Integration of Multi-omics Studies for OsteoporosisU19AG055373 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI YU-PING WANG · 2017 to 2026
$24.3M
NIA NIH HHS U19 AG055373NIGMS NIH HHS P20 GM103424NIMHD NIH HHS U54 MD007595
6 · The paper itself

Abstract

Prostate cancer susceptibility is a polygenic trait. We aimed to examine the controversial diagnostic utility of single-nucleotide polymorphisms (SNP) for prostate cancer. We analyzed two datasets collected from Europeans and one from Africans. These datasets were generated by the genome-wide association studies, that is, CGEMS, BPC3, and MEC-Africans, respectively. About 540,000 SNPs, including 61 risk markers that constitute a panel termed MK-61, were commonly genotyped. For each dataset, we augmented the MK-61 panel to generate an MK-61

Indexed as

AgedBiomarkers, TumorCase-Control StudiesDatasets as TopicFollow-Up StudiesGenetic Predisposition to DiseaseGenome-Wide Association StudyGerm CellsHumansMaleMiddle AgedPolymorphism, Single NucleotidePrevalencePrognosisProstatic NeoplasmsRisk AssessmentBiomarkers, Tumor

Identifiers

PMID33866309
PMCPMC8295202
OpenAlexW3155566609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.