ArticleMolecular and cellular biology1988
A fragile site in the human U2 small nuclear RNA gene cluster is revealed by adenovirus type 12 infection.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- A tandem array of minimal U1 small nuclear RNA genes is sufficient to generate a new adenovirus type 12-inducible chromosome fragile site.Journal of virology · 1998Article
- Adenovirus type 12-induced fragility of the human RNU2 locus requires p53 function.Journal of virology · 1998Article
- Adenovirus type 12-induced fragility of the human RNU2 locus requires U2 small nuclear RNA transcriptional regulatory elements.Molecular and cellular biology · 1995Article
- The transcriptionally competent U2 gene is necessary and sufficient for adenovirus type 12 induction of the fragile site at 17q21-22.Molecular and cellular biology · 1995Article
- Concerted evolution of the tandem array encoding primate U2 snRNA occurs in situ, without changing the cytological context of the RNU2 locus.The EMBO journal · 1995Article
- Generation of a new adenovirus type 12-inducible fragile site by insertion of an artificial U2 locus in the human genome.Molecular and cellular biology · 1993Article
- MT-III, a brain-specific member of the metallothionein gene family.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Structure and evolution of the U2 small nuclear RNA multigene family in primates: gene amplification under natural selection?Molecular and cellular biology · 1990Article
- Chromosomal damage induced by human adenovirus type 12 requires expression of the E1B 55-kilodalton viral protein.Journal of virology · 1990Article
- Viral integration, fragile sites, and proto-oncogenes in human neoplasia.Human genetics · 1990Article
- A retroposon-like short repetitive DNA element in the genome of the human blood fluke, Schistosoma mansoni.Chromosoma · 1989Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using in situ hybridization, we found that the U2 small nuclear RNA gene cluster mapped very close to and was frequently disrupted by the gaps and breaks induced specifically in the human 17q21-q22 region by highly oncogenic adenovirus type 12 (Ad12). Restriction mapping revealed no structural alterations in the U2 gene locus as a result of Ad12 infection. Likewise, no Ad12-induced alterations in U2 RNA levels were detected. We estimate that the maximum size of the region specifically disrupted by this virus was less than 350 to 700 kilobases. A comparison of these data with similar data regarding biochemically induced fragile sites was made.
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