Evidence map›Paper›PMID 33866072›Full record

ArticleDrug and alcohol dependence2021

Investigating sex differences in acute intoxication and verbal memory errors after ad libitum cannabis concentrate use.

Laurel P Gibson, Charleen J Gust, Jarrod M Ellingson, Sophie L YorkWilliams, Cristina Sempio, Jost Klawitter, Angela D Bryan, Kent E Hutchison, L Cinnamon Bidwell

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laurel P GibsonDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA. Electronic address: laurel.gibson@colorado.edu.
Charleen J GustDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA.
Jarrod M EllingsonDivision of Substance Dependence, Department of Psychiatry, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Mail Stop F570, Aurora, CO, 80045, USA.
Sophie L YorkWilliamsDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA.
Cristina SempioDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, 12705 East Montview Blvd, Suite 200, Aurora, CO, 80045, USA.
Jost KlawitterDivision of Substance Dependence, Department of Psychiatry, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, Mail Stop F570, Aurora, CO, 80045, USA; Department of Anesthesiology, University of Colorado Anschutz Medical Campus, 12705 East Montview Blvd, Suite 200, Aurora, CO, 80045, USA.
Angela D BryanDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA; Institute of Cognitive Science, University of Colorado, 344 UCB, Boulder, CO, 80309-0344, USA.
Kent E HutchisonDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA; Institute of Cognitive Science, University of Colorado, 344 UCB, Boulder, CO, 80309-0344, USA.
L Cinnamon BidwellDepartment of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA; Institute of Cognitive Science, University of Colorado, 344 UCB, Boulder, CO, 80309-0344, USA.
University of Colorado Boulder · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Common mechanisms of the microbiota-gut-brain axis in alcohol use disorder and depression: A genetically informed investigationK23AA026635 · NIAAA · UNIVERSITY OF COLORADO DENVER · PI ELLINGSON, JARROD MARTIN · 2018 to 2022
$907k
NIAAA NIH HHS K23 AA026635
6 · The paper itself

Abstract

backgroundAn innovative naturalistic at-home administration procedure was used to investigate sex differences in subjective drug effects and verbal memory errors after ad libitum use of high potency state legal market Δ9-tetrahydrocannabinol (THC) concentrate.

methodsRegular concentrate users were randomly assigned to ad libitum administration of one of two cannabis concentrate products (70 % or 90 % THC) that they purchased from a dispensary. 65 participants (N = 34 men, N = 31 women) were assessed in a mobile pharmacology lab before, immediately after, and 1 -h after ad libitum concentrate use. Plasma cannabinoids (THC, 11-OH-THC, CBD), subjective drug effects, and verbal memory errors were assessed at all three time points.

resultsAlthough men and women exhibited similar plasma 11-OH-THC levels across time (p = .10), sex differences were found in plasma THC and CBD after legal market concentrate use, with men displaying significantly higher levels of plasma THC and CBD immediately after cannabis concentrate use (plasma THC [ng/mL]: M

conclusionThese data provide the first look at sex differences after acute naturalistic cannabis concentrate use, and suggest much higher THC exposure in men versus women, but similar acute drug and impairment effects across the sexes. Further studies are needed to determine the mechanisms (e.g. tolerance, cannabinoid metabolism, smoking topography) behind these findings.

Indexed as

CannabidiolCannabinoidsCannabisHallucinogensMarijuana SmokingDronabinolHumansSex CharacteristicsCannabidiolCannabinoidsDronabinolHallucinogensAbuse liabilityCannabinoidsHigh-potencyMarijuanaMemorySex

Identifiers

PMID33866072
PMCPMC9357512
OpenAlexW3156072588

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.