Evidence map›Paper›PMID 33866067›Full record

ArticlePsychoneuroendocrinology2021

The association between COVID-19 pandemic and maternal isolated hypothyroxinemia in first and second trimesters.

Jing Hua, Jiajin Shen, Jiajia Zhang, Yingchun Zhou, Wenchong Du, Gareth J Williams

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Article in Psychoneuroendocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jing HuaShanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 2699, Gaoke Road, Pudong District, Shanghai 201204, China. Electronic address: jinghua@tongji.edu.cn.
Jiajin ShenKLATASDS-MOE, School of Statistics, East China Normal University, North Zhangshan Road, Shanghai，Pudong District, Shanghai 200062, China. Electronic address: jiajin_shen@hotmail.com.
Jiajia ZhangShanghai First Maternity and Infant Hospital, Tongji University School of Medicine, 2699, Gaoke Road, Pudong District, Shanghai 201204, China. Electronic address: zhangjiajia2019@tongji.edu.cn.
Yingchun ZhouKLATASDS-MOE, School of Statistics, East China Normal University, North Zhangshan Road, Shanghai，Pudong District, Shanghai 200062, China. Electronic address: yczhou@stat.ecnu.edu.cn.
Wenchong DuDepartment of psychology, Nottingham Trent University, Burton Street, Nottingham NG1 4BU, UK. Electronic address: vivienne.du@ntu.ac.uk.
Gareth J WilliamsSchool of Social Sciences, Nottingham Trent University, 3633, Burton Street, Nottingham NG1 4BU, UK. Electronic address: gareth.williams@ntu.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe outbreak of COVID-19 epidemic has induced entire cities in China placed under 'mass quarantine'. The majority of pregnant women have to be confined at home may be more vulnerable to stressors. In our study, we aimed to explore the effects of the epidemic on maternal thyroid function, so as to provide evidence for prevention and intervention of sustained maternal and offspring's health impairment produced by thyroid dysfunction.

methodsThe subjects were selected from an ongoing prospective cohort study. we included the pregnant women who receive a thyroid function test during the COVID-19 epidemic and those receiving the test during the corresponding lunar period of 2019. A total of 7148 pregnant women with complete information were included in the final analysis. Multivariate linear and logistic regression models were used for analyzing the association of COVID-19 pandemic with FT4 levels and isolated hypothyroxinemia.

resultsWe found a decreased maternal FT4 level during the period of the COVID-19 pandemic in first and second trimesters (β = -0. 131, 95%CI = -0.257,-0.006，p = 0.040) and in first trimester (β = -0. 0.176, 95%CI = -0.326,-0.026，p = 0.022) when adjusting for 25 (OH) vitamin D, vitamin B12, folate and ferritin and gestational days, maternal socio-demographic characteristics and health conditions. The status of pandemic increased the risks of isolated hypothyroxinemia in first and second trimesters (OR = 1.547, 95%CI = 1.251,1.913, p < 0.001) and first trimester (OR = 1.651, 95%CI = 1.289,2.114, p < 0.001) when adjusting for the covariates. However, these associations disappeared in the women with positive TPOAb (p > 0.05). Additionally, we found associations between daily reported new case of COVID-19 and maternal FT4 for single-day lag1, lag3 and multi-day lag01 and lag04 when adjusting for the covariates (each p < 0.05).

conclusionsMass confinement as a primary community control strategy may have a significant cost to public health resources. Access to health service systems and adequate medical resources should be improved for pregnant women during the COVID-19 pandemic.

Indexed as

QuarantineAdultChinaCOVID-19FemaleHumansPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPregnancy Trimester, SecondProspective StudiesThyroid DiseasesThyroxineThyroxineCOVID-19 pandemicMaternal isolated hypothyroxinemiaPregnant womenStress-related

Identifiers

PMID33866067
PMCPMC8021450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.