Evidence map›Paper›PMID 33865691›Full record

ArticleJournal of substance abuse treatment2021

Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adults (EXIT-CJS).

Elizabeth Needham Waddell, Sandra A Springer, Lisa A Marsch, David Farabee, Robert P Schwartz, Amesika Nyaku, Rusty Reeves, Keith Goldfeld, Ryan D McDonald, Mia Malone and 15 more

Open access · greenAbstract readClinical Trial Protocol
In one paragraph

Article in Journal of substance abuse treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Sustained-release naltrexone for opioid dependence.The Cochrane database of systematic reviews · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Elizabeth Needham WaddellSchool of Public Health and OHSU School of Medicine, Oregon Health & Science University, United States of America.
Sandra A SpringerDartmouth College, United States of America.
Lisa A MarschDartmouth College, United States of America.
David FarabeeNYU Grossman SOM, United States of America.
Robert P SchwartzFriends Research Institute, United States of America.
Amesika NyakuThe State University of New Jersey, New Jersey Medical School, United States of America.
Rusty ReevesRutgers, University Correctional Health Care, Rutgers - Robert Wood Johnson Medical School, United States of America.
Keith GoldfeldNYU Grossman SOM, United States of America.
Ryan D McDonaldNYU Grossman SOM, United States of America.
Mia MaloneFriends Research Institute, United States of America.
Anna ChengFriends Research Institute, United States of America.
Elizabeth C SaundersDartmouth College, United States of America.
Laura MonicoFriends Research Institute, United States of America.
Jan GryczynskiFriends Research Institute, United States of America.
Kathleen BellDartmouth College, United States of America.
Kasey HardingCommunity Health Center, Inc, United States of America.
Sandra VioletteConnecticut Dept. of Corrections, United States of America.
Thomas GroblewskiNew Hampshire Dept. of Corrections, United States of America.
Wendy MartinROAD to a Better Life, United States of America.
Kasey TalonROAD to a Better Life, United States of America.
Nicole BeckwithROAD to a Better Life, United States of America.
Andrew SuchockiClackamas County Health Centers, United States of America.
Randy TorralvaCODA Inc., United States of America.
Jennifer P WisdomCODA Inc., United States of America.
Joshua D LeeNYU Grossman SOM, United States of America. Electronic address: Joshua.Lee@nyulangone.org.
Friends Research Institute · USDartmouth College · US

Funding

Treatment Development & Evaluation CoreP30DA029926 · NIDA · DARTMOUTH COLLEGE · PI Lisa A. Marsch · 2011 to 2026
$21.5M
Long-acting buprenorphine vs. naltrexone opioid treatments in CJS-involved adultsU01DA047982 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FARABEE, DAVID J, GRYCZYNSKI, JAN · 2019 to 2024
$20.3M
Impact of Jail-Based Methadone on Overdose, Recidivism, HIV and Health Outcomes, and Costs in New York City, 2011-2017R01DA045042 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEE, JOSHUA D, LIM, SUNGWOO · 2018 to 2022
$3.1M
Reducing Overdose After Release from Incarceration (ROAR)R01CE003008 · CE · OREGON HEALTH & SCIENCE UNIVERSITY · PI WADDELL, ELIZABETH NEEDHAM · 2018 to 2020
$2.2M
Assessing Optimal XR-Buprenorphine Initiation Points in JailR01DA056446 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FARABEE, DAVID J, STOPKA, THOMAS J · 2022 to 2024
$1.9M
Medication Assisted Therapy as a Conduit to Care for HIV+ CJS Populations TransitK02DA032322 · NIDA · YALE UNIVERSITY · PI SPRINGER, SANDRA ANN · 2011 to 2022
$1.3M
NCIPC CDC HHS R01 CE003008NIDA NIH HHS K02 DA032322NIDA NIH HHS P30 DA029926NIDA NIH HHS R01 DA056446NIDA NIH HHS U01 DA047982
6 · The paper itself

Abstract

The EXIT-CJS (N = 1005) multisite open-label randomized controlled trial will compare retention and effectiveness of extended-release buprenorphine (XR-B) vs. extended-release naltrexone (XR-NTX) to treat opioid use disorder (OUD) among criminal justice system (CJS)-involved adults in six U.S. locales (New Jersey, New York City, Delaware, Oregon, Connecticut, and New Hampshire). With a pragmatic, noninferiority design, this study hypothesizes that XR-B (n = 335) will be noninferior to XR-NTX (n = 335) in retention-in-study-medication treatment (the primary outcome), self-reported opioid use, opioid-positive urine samples, opioid overdose events, and CJS recidivism. In addition, persons with OUD not eligible or interested in the RCT will be recruited into an enhanced treatment as usual arm (n = 335) to examine usual care outcomes in a quasi-experimental observational cohort.

Indexed as

BuprenorphineOpioid-Related DisordersAdultAnalgesics, OpioidDelayed-Action PreparationsHumansInjections, IntramuscularNaltrexoneNarcotic AntagonistsPragmatic Clinical Trials as TopicAnalgesics, OpioidBuprenorphineDelayed-Action PreparationsNaltrexoneNarcotic AntagonistsBuprenorphineCriminal justiceInjectionMedication treatmentNaltrexoneOpioid use disorder

Identifiers

PMID33865691
PMCPMC8384640
OpenAlexW3156290283

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.