ArticleBritish journal of anaesthesia2021
Relationships between preoperative cortical thickness, postoperative electroencephalogram slowing, and postoperative delirium.
Article in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03124303 (Interventions for Postoperative Delirium), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interventions for Postoperative Delirium: Biomarker-3
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Study on EEG neural oscillation characteristics during ciprofol general anesthesia.Journal of anesthesia · 2026Observational
- Perioperative neurocognitive disorders in older patients: a narrative review of current knowledge in 2026.Perioperative medicine (London, England) · 2026Review
- [Effect of intraoperative dexmedetomidine on postoperative sleep disturbance in elderly surgical patients: a prospective multicenter cohort study].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026Observational
- Dysfunctional resting state network connectivity predicts postoperative delirium after major surgery.British journal of anaesthesia · 2026Article
- Predictive role of tear metabolomics in delirium during anesthesia emergence and postoperative period in elderly patients after abdominal surgery.Frontiers in molecular biosciences · 2026Article
- Evidence for cognitive compensation mechanism in the postoperative delirium: a prospective multi-modal neuroimaging cohort study.Brain imaging and behavior · 2025Article
- Preoperative Cholinergic Signatures Drive Segregated Brain Architecture in Postoperative Delirium.Research square · 2025Article
- Article
- Developing predictive nomogram models using quantitative electroencephalography for brain function in type a aortic dissection: a prospective observational study.International journal of surgery (London, England) · 2025Observational
- Postoperative sepsis-associated neurocognitive disorder: mechanisms, predictive strategies, and treatment approaches.Frontiers in medicine · 2025Review
- A longitudinal multimodal MRI study of the visual network in postoperative delirium.Brain imaging and behavior · 2024Article
- Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients.Neurobiology of aging · 2024Article
- A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- The U-shaped curve predicting cognitive vulnerability to delirium severity.Brain : a journal of neurology · 2023Article
- Reduced Electroencephalogram Complexity in Postoperative Delirium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Impact of postoperative delirium on days alive and at home after surgery: a prospective cohort study.British journal of anaesthesia · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIt is unclear how preoperative neurodegeneration and postoperative changes in EEG delta power relate to postoperative delirium severity. We sought to understand the relative relationships between neurodegeneration and delta power as predictors of delirium severity.
methodsWe undertook a prospective cohort study of high-risk surgical patients (>65 yr old) to identify predictors of peak delirium severity (Delirium Rating Scale-98) with twice-daily delirium assessments (NCT03124303). Participants (n=86) underwent preoperative MRI; 54 had both an MRI and a postoperative EEG. Cortical thickness was calculated from the MRI and delta power from the EEG.
resultsIn a linear regression model, the interaction between delirium status and preoperative mean cortical thickness (suggesting neurodegeneration) across the entire cortex was a significant predictor of delirium severity (P<0.001) when adjusting for age, sex, and performance on preoperative Trail Making Test B. Next, we included postoperative delta power and repeated the analysis (n=54). Again, the interaction between mean cortical thickness and delirium was associated with delirium severity (P=0.028), as was postoperative delta power (P<0.001). When analysed across the Desikan-Killiany-Tourville atlas, thickness in multiple individual cortical regions was also associated with delirium severity.
conclusionsPreoperative cortical thickness and postoperative EEG delta power are both associated with postoperative delirium severity. These findings might reflect different underlying processes or mechanisms. CLINICAL
trial registrationNCT03124303.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.