ReviewThe Lancet. Global health2021
Urgently seeking efficiency and sustainability of clinical trials in global health.
Review in The Lancet. Global health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Impacts of clinical research units on clinical research - a systematic review of empirical studies.Systematic reviews · 2025Pooled it
- A rapid review of community engagement and informed consent processes for adaptive platform trials and alternative design trials for public health emergencies.Wellcome open research · 2023Pooled it
- A Review of the Ring Trial Design for Evaluating Ring Interventions for Infectious Diseases.Epidemiologic reviews · 2022Pooled it
- Training Needs Assessment and Capacity Building of Clinical Trial Assessors and Ethical Reviewers to Strengthen Regulatory Review in Tanzania.Therapeutic innovation & regulatory science · 2026Article
- Building a case for accelerated clinical development of drugs and vaccines - what are the driving forces?Globalization and health · 2026Article
- A scoping review of randomized controlled trials in the early phase of the COVID-19 pandemic: country-level research response to COVID-19 therapeutics and vaccines.BMC infectious diseases · 2026Article
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- Three decades of clinical trials in Portuguese-speaking Africa: a comprehensive scoping review protocol.BMJ open · 2026Article
- Global clinical trial landscape of stem cell-based therapies for osteoarthritis: trends and translational implications.Frontiers in cell and developmental biology · 2026Article
- Establishing best practices guidelines for collaborative research in global surgery: developing a Delphi survey.Journal of global health · 2025Article
- A call to strengthen clinical trials capacity in resource-limited settings.BMJ global health · 2025Article
- Inequalities in access to industry-funded interventional phase I-IV drug trials in epilepsy.Epilepsia open · 2025Article
- Platform trials-an emerging methodology for perioperative medicine: a narrative review.Perioperative medicine (London, England) · 2025Review
- Trials special series - the collection, analysis and reporting of adverse events in randomised controlled trials.Trials · 2025Article
- Establishing clinical research networks for future infectious disease outbreak responses in Southeast Asia: Report of a workshop on challenges and opportunities.IJID regions · 2025Review
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- Article
- Oncology Early-Phase Clinical Trials in the Middle East and North Africa: A Review of the Current Status, Challenges, Opportunities, and Future Directions.Journal of immunotherapy and precision oncology · 2024Review
- Understanding Heterogeneity in Acute Care Trials: Resource Availability Impacts Outcomes.American journal of respiratory and critical care medicine · 2024Article
- Article
Corrections and comments
- Commented on by
Authors and funding
13 authors.
Funding
Abstract
This paper shows the scale of global health research and the context in which we frame the subsequent papers in the Series. In this Series paper, we provide a historical perspective on clinical trial research by revisiting the 1948 streptomycin trial for pulmonary tuberculosis, which was the first documented randomised clinical trial in the English language, and we discuss its close connection with global health. We describe the current state of clinical trial research globally by providing an overview of clinical trials that have been registered in the WHO International Clinical Trial Registry since 2010. We discuss challenges with current trial planning and designs that are often used in clinical trial research undertaken in low-income and middle-income countries, as an overview of the global health trials landscape. Finally, we discuss the importance of collaborative work in global health research towards generating sustainable and culturally appropriate research environments.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.