ArticleJournal of eating disorders2021
Changes in brain and behavior during food-based decision-making following treatment of anorexia nervosa.
Article in Journal of eating disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered value-based decision-making in anorexia nervosa: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Optimizing relapse prevention and changing habits (REACH+) in anorexia nervosa.The International journal of eating disorders · 2022Trial
- Different brain regions support deliberation during food choice in disordered and healthy eating.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- When tasty becomes threatening: a neurobehavioral perspective on subjective food preferences in eating disorders.Frontiers in psychology · 2026Review
- Different brain regions support deliberation during food choice in disordered and healthy eating.Research square · 2025Article
- Exploring Habits in Anorexia Nervosa: Promise, Pitfalls, and Progress.Current psychiatry reports · 2025Review
- Eating disorder symptoms and emotional arousal modulate food biases during reward learning in females.Nature communications · 2025Article
- Food choice and neural reward systems in adolescents with anorexia nervosa and atypical anorexia nervosa.Journal of child psychology and psychiatry, and allied disciplines · 2025Article
- Nucleus accumbens deep brain stimulation in adult patients suffering from severe and enduring anorexia nervosa (STIMARS): protocol for a pilot study.Frontiers in psychiatry · 2025Article
- Reward Reinforcement Creates Enduring Facilitation of Goal-directed Behavior.Journal of cognitive neuroscience · 2024Article
- Altered learning from positive feedback in adolescents with anorexia nervosa.Journal of the International Neuropsychological Society : JINS · 2024Article
- A transdiagnostic and translational framework for delineating the neuronal mechanisms of compulsive exercise in anorexia nervosa.The International journal of eating disorders · 2024Review
- Reduced dorsal fronto-striatal connectivity at rest in anorexia nervosa.Psychological medicine · 2024Article
- Reducing Relapse by Enhancing Reward Responsivity in Anorexia Nervosa: The VIBRANT (Virtual Interventions for Bolstering Recovery following Anorexia Nervosa Treatment) TrialJournal of psychiatry and brain science · 2024Article
- Habits and Persistent Food Restriction in Patients with Anorexia Nervosa: A Scoping Review.Behavioral sciences (Basel, Switzerland) · 2023Article
- Beyond Description and Deficits: How Computational Psychiatry Can Enhance an Understanding of Decision-Making in Anorexia Nervosa.Current psychiatry reports · 2022Review
- Anhedonia in Eating Disorders.Current topics in behavioral neurosciences · 2022Article
- Use of high-frequency repetitive transcranial magnetic stimulation to probe the neural circuitry of food choice in anorexia nervosa: A proof-of-concept study.The International journal of eating disorders · 2021Article
- Associations between mealtime anxiety and food intake in anorexia nervosa.The International journal of eating disorders · 2021Article
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Authors and funding
6 authors.
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Abstract
backgroundAnorexia nervosa is a severe illness with a high mortality rate, driven in large part by severe and persistent restriction of food intake. A critical challenge is to identify brain mechanisms associated with maladaptive eating behavior and whether they change with treatment. This study tested whether food choice-related caudate activation in anorexia nervosa changes with treatment.
methodsHealthy women (n = 29) and women hospitalized with anorexia nervosa (n = 24), ages 18 to 40 years, completed a Food Choice Task during fMRI scanning at two timepoints. Among patients, procedures occurred upon hospital admission (Time 1) and again after patients had gained to normal weight (Time 2). Healthy controls were tested twice at an interval group-matched to patients. Choice-related caudate activation was assessed at each timepoint, using parametric analyses in an a priori region of interest.
resultsAmong patients, the proportion of high-fat foods selected did not change over time (p's > 0.47), but decreased neural activity in the caudate after treatment was associated with increased selection of high-fat foods (r
conclusionsCaudate activity was more strongly associated with decisions about food among individuals with anorexia nervosa relative to healthy comparison individuals prior to treatment, and decreases in caudate engagement among individuals with anorexia nervosa undergoing treatment were associated with increases in high-fat food choices. The findings underscore the need for treatment development that more successfully alters both eating behavior and the neural mechanisms that guide it.
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