Evidence map›Paper›PMID 33865073›Full record

ArticleVirology2021

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8

Blake Schouest, Brandon J Beddingfield, Margaret H Gilbert, Rudolf P Bohm, Faith Schiro, Pyone P Aye, Antonito T Panganiban, Diogo M Magnani, Nicholas J Maness

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
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  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Blake SchouestTulane National Primate Research Center, Tulane University, Covington, LA, USA; Biomedical Sciences Training Program, Tulane University School of Medicine, New Orleans, LA, USA.
Brandon J BeddingfieldTulane National Primate Research Center, Tulane University, Covington, LA, USA.
Margaret H GilbertTulane National Primate Research Center, Tulane University, Covington, LA, USA.
Rudolf P BohmTulane National Primate Research Center, Tulane University, Covington, LA, USA.
Faith SchiroTulane National Primate Research Center, Tulane University, Covington, LA, USA.
Pyone P AyeTulane National Primate Research Center, Tulane University, Covington, LA, USA.
Antonito T PanganibanTulane National Primate Research Center, Tulane University, Covington, LA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA.
Diogo M MagnaniDepartment of Medicine, University of Massachusetts, Boston, MA, USA.
Nicholas J ManessTulane National Primate Research Center, Tulane University, Covington, LA, USA; Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, LA, USA. Electronic address: nmaness@tulane.edu.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
NIH HHS P51 OD011104
6 · The paper itself

Abstract

While T cell immunity is an important component of the immune response to Zika virus (ZIKV) infection generally, the efficacy of these responses during pregnancy remains unknown. Here, we tested the capacity of CD8 lymphocytes to protect from secondary challenge in four macaques, two of which were depleted of CD8

Indexed as

AnimalsAntibodies, NeutralizingCD8-Positive T-LymphocytesChlorocebus aethiopsCoinfectionFemaleGene Expression ProfilingKineticsMacacaPregnancyVero CellsZika VirusZika Virus InfectionAntibodies, NeutralizingCD8(+) T cellsMacaquesNonhuman primatesPregnancyZika virus

Identifiers

PMID33865073
PMCPMC8212702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.