Evidence map›Paper›PMID 33864933›Full record

ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2022

Doylestown Plus and GALAD Demonstrate High Sensitivity for HCC Detection in Patients With Cirrhosis.

Amit G Singal, Nabihah Tayob, Anand Mehta, Jorge A Marrero, Qingchun Jin, Joy Lau, Neehar D Parikh

Open access · greenAbstract readClinical Study
In one paragraph

Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 35 citations in OpenAlex.

  1. Trial
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  5. Early screening for liver cancer must be performed.World journal of hepatology · 2025
    Review
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  7. [Current status and prospects for screening early-stage hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2025
    Review
  8. Article
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  11. Alpha-fetoprotein: Past, present, and future.Hepatology communications · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Amit G SingalDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas. Electronic address: amit.singal@utsouthwestern.edu.
Nabihah TayobDepartment of Data Science, Dana Farber Cancer Center, Boston, Massachusetts.
Anand MehtaDepartment of Internal Medicine, Medical University of South Carolina, Charleston, South Carolina.
Jorge A MarreroDepartment of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas; Harold C. Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas.
Qingchun JinDepartment of Data Science, Dana Farber Cancer Center, Boston, Massachusetts.
Joy LauDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Neehar D ParikhDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Dana-Farber Cancer Institute · USSouthwestern Medical Center · USUniversity of Michigan · USMedical University of South Carolina · US

Funding

Consortium on Translational Research in Early Detection of Liver Cancer:Data Management and Coordinating Center (DMCC)U24CA230144 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Ziding Feng · 2018 to 2026
$5.8M
Predicting HCC through GlycomicsR01CA120206 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MEHTA, ANAND S. · 2006 to 2016
$4.3M
Precision Risk Stratification and Screening for HCC among Patients with Cirrhosis in the United StatesU01CA230694 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT · 2018 to 2022
$3.5M
Glycopathology of HCC: identification of the source cells of serum fucosylationU01CA226052 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DRAKE, RICHARD R., HOSHIDA, YUJIN · 2019 to 2023
$2.8M
Translation of a biomarker panel for the early detection of hepatocellular carcinomaR01CA237659 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MARRERO, JORGE A, MEHTA, ANAND S. · 2019 to 2023
$2.5M
Precision Screening for Hepatocellular Carcinoma in Patients with CirrhosisR01CA222900 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI SINGAL, AMIT · 2018 to 2023
$2.4M
Biomarker screening algorithms for the improved early detection of hepatocellular carcinomaR01CA230503 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI TAYOB, NABIHAH · 2019 to 2025
$1.6M
NCI NIH HHS R01 CA120206NCI NIH HHS R01 CA222900NCI NIH HHS R01 CA230503NCI NIH HHS R01 CA237659NCI NIH HHS U01 CA226052NCI NIH HHS U01 CA230694NCI NIH HHS U24 CA230144
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) surveillance is associated with early tumor detection and improved survival in patients with cirrhosis.

Indexed as

Carcinoma, HepatocellularLiver Neoplasmsalpha-FetoproteinsBiomarkersBiomarkers, TumorCase-Control StudiesHumansLiver CirrhosisSensitivity and Specificityalpha-FetoproteinsBiomarkersBiomarkers, Tumor

Identifiers

PMID33864933
PMCPMC8526617
OpenAlexW3156321286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.