ArticleThe Journal of hospital infection2021
An automated room disinfection system using ozone is highly active against surrogates for SARS-CoV-2.
Article in The Journal of hospital infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Micro and nanobubbles enhanced ozonation technology: A synergistic approach for pesticides removal.Comprehensive reviews in food science and food safety · 2025Pooled it
- Disinfection methods against SARS-CoV-2: a systematic review.The Journal of hospital infection · 2022Pooled it
- Article
- Advances in Ozone-Based Inactivation of SARS-CoV-2: An Updated Review.International journal of molecular sciences · 2026Review
- Targeted phage aerosol for environmental control of CR-Kpn in the ICU: a prospective intervention study.Frontiers in public health · 2026Article
- Infectivity duration of HCoV-OC43, a surrogate for SARS-CoV-2, in artificial bodily fluids on stainless steel simulating common nonporous surfaces.Microbiology spectrum · 2025Article
- Aerostability of Sin Nombre Virus Aerosol Related to Near-Field Transmission.Pathogens (Basel, Switzerland) · 2025Article
- Development and application of decontamination methods for the re-use of laboratory grade plastic pipette tips.PloS one · 2024Article
- Hygiene requirements for cleaning and disinfection of surfaces: recommendation of the Commission for Hospital Hygiene and Infection Prevention (KRINKO) at the Robert Koch Institute.GMS hygiene and infection control · 2024Article
- An Assessment of Germicidal Ultraviolet Treatment Cabinets and Carousels Using a Bacteriophage Surface Challenge.Applied biosafety : journal of the American Biological Safety Association · 2023Article
- Novel intrathoracic irrigation using ultrafine ozone bubbles in a rat empyema model.Scientific reports · 2023Article
- Ozone based inactivation and disinfection in the pandemic time and beyond: Taking forward what has been learned and best practice.The Science of the total environment · 2023Review
- Ozone application in different industries: A review of recent developments.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Review
- Infectivity of SARS-CoV-2 on Inanimate Surfaces: Don't Trust Ct Value.International journal of environmental research and public health · 2022Article
- Article
- Ozone Eliminates SARS-CoV-2 from Difficult-to-Clean Office Supplies and Clinical Equipment.International journal of environmental research and public health · 2022Article
- Associations between the COVID-19 Pandemic and Hospital Infrastructure Adaptation and Planning-A Scoping Review.International journal of environmental research and public health · 2022Article
- Potent Activity of a High Concentration of Chemical Ozone against Antibiotic-Resistant Bacteria.Molecules (Basel, Switzerland) · 2022Article
- Antiviral Characterization of Advanced Materials: Use of Bacteriophage Phi 6 as Surrogate of Enveloped Viruses Such as SARS-CoV-2.International journal of molecular sciences · 2022Review
- Ozone as an alternative decontamination process for N95 facemask and biosafety gowns.Materials letters · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of coronaviruses on surfaces in the patient environment is a potential source of indirect transmission. Manual cleaning and disinfection measures do not always achieve sufficient removal of surface contamination. This increases the importance of automated solutions in the context of final disinfection of rooms in the hospital setting. Ozone is a highly effective disinfectant which, combined with high humidity, is an effective agent against respiratory viruses. Current devices allow continuous nebulization for high room humidity as well as ozone production without any consumables.
aimIn the following study, the effectiveness of a fully automatic room decontamination system based on ozone was tested against bacteriophage Φ6 (phi 6) and bovine coronavirus L9, as surrogate viruses for the pandemic coronavirus SARS-CoV-2.
methodsFor this purpose, various surfaces (ceramic tile, stainless steel surface and furniture board) were soiled with the surrogate viruses and placed at two different levels in a gas-tight test room. After using the automatic decontamination device according to the manufacturer's instructions, the surrogate viruses were recovered from the surfaces and examined by quantitative cultures. Then, reduction factors were calculated.
findingsThe ozone-based room decontamination device achieved virucidal efficacy (reduction factor >4 log
conclusionOzone is highly active against SARS-CoV-2 surrogate organisms. Further investigations are necessary for a safe application and efficacy in practice as well as integration into routine processes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.