Evidence map›Paper›PMID 33864607›Full record

Trial reportEndocrine2021

Changes in white adipose tissue gene expression in a randomized control trial of dieting obese men with lowered serum testosterone alone or in combination with testosterone treatment.

Mathis Grossmann, Mark Ng Tang Fui, Tian Nie, Rudolf Hoermann, Michele V Clarke, Ada S Cheung, Jeffrey D Zajac, Rachel A Davey

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Endocrine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01616732 (Effect of Testosterone and Diet on Weight), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01616732 phase2completednot on this map

Effect of Testosterone and Diet on Weight

TypeinterventionalSponsorAustin HealthRan2013 to 2015Enrolled100ConditionsObesity in MenArmsTestosterone, placebo
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mathis GrossmannDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0001-8261-3457
Mark Ng Tang FuiDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0002-5101-8572
Tian NieDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0001-7426-0356
Rudolf HoermannDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0002-1326-4270
Michele V ClarkeDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.
Ada S CheungDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0001-5257-5525
Jeffrey D ZajacDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia.ORCID 0000-0003-3933-5708
Rachel A DaveyDepartment of Medicine Austin Health, University of Melbourne, Heidelberg, Victoria, Australia. r.davey@unimelb.edu.au.ORCID 0000-0001-5121-0209
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to determine early weight loss-associated changes in subcutaneous abdominal white adipose tissue (WAT) gene expression in obese men with lowered serum testosterone by RNA next-generation sequencing.

methodsFourteen men, mean age (IQR) 51.6 years (43.4-54.5), BMI 38.3 kg/m

resultsBody weight loss was similar in participants receiving testosterone (n = 6), -5.27 kg [95% CI -6.17; -4.26], and placebo (n = 8), -4.57 kg [95% CI -6.10; -3.55], p = 0.86. In placebo-treated men, of the 14,410 genes expressed in subcutaneous WAT, four genes, Angiopoietin-like 4, Semaphorin 3 G, Neuropilin 2 and Angiopoietin 4, were upregulated (adjusted false discovery rate P < 0.05). In an exploratory analysis comparing men receiving testosterone and placebo, the most-upregulated gene in the testosterone group (exploratory p < 0.0005) was the neuropeptide y receptor 2.

conclusionsIn obese men, dieting is associated with upregulation of WAT-expressed Angiopoietin-like 4, a secreted protein that regulates lipid metabolism, Semaphorin 3 G, a proposed adipocyte differentiation factor and secreted adipokine, and its receptor Neuropilin 2, as well as Angiopoietin 4, a vascular integrity factor. In an exploratory analysis, testosterone was associated with the upregulation of neuropeptide y receptor 2, a receptor involved in appetite regulation. Further studies are needed to confirm these observations and their potential biological implications.

trial registrationclinicaltrials.gov, Identifier NCT01616732, Registration date: June 8, 2012.

Indexed as

Adipose Tissue, WhiteTestosteroneAbdominal FatChild, PreschoolGene ExpressionHumansInfantMaleObesityTestosteroneGene expressionObesityTestosteroneWhite adipose tissue

Identifiers

PMID33864607
OpenAlexW3154594158

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.