ArticleProtein science : a publication of the Protein Society2021
Macromolecular regulators have matching effects on the phase equilibrium and interfacial tension of biomolecular condensates.
Article in Protein science : a publication of the Protein Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A pH-Centric Model of Nucleolar Activity and Regulation.Journal of molecular biology · 2025Review
- Amino acid-dependent phase equilibrium and material properties of tetrapeptide condensates.Cell reports. Physical science · 2024Article
- Fundamental Aspects of Phase-Separated Biomolecular Condensates.Chemical reviews · 2024Review
- Amino Acid-Dependent Material Properties of Tetrapeptide Condensates.bioRxiv : the preprint server for biology · 2024Article
- Determinants of viscoelasticity and flow activation energy in biomolecular condensates.Science advances · 2024Article
- Proximity to criticality predicts surface properties of biomolecular condensates.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Multiscale Modeling of Protein-RNA Condensation in and Out of Equilibrium.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Calculating Binodals and Interfacial Tension of Phase-Separated Condensates from Molecular Simulations with Finite-Size Corrections.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Macromolecular Regulation of the Material Properties of Biomolecular Condensates.The journal of physical chemistry letters · 2022Article
- Multiphase organization is a second phase transition within multi-component biomolecular condensates.The Journal of chemical physics · 2022Article
- RNA chain length and stoichiometry govern surface tension and stability of protein-RNA condensates.iScience · 2022Article
- SpiDec: Computing binodals and interfacial tension of biomolecular condensates from simulations of spinodal decomposition.Frontiers in molecular biosciences · 2022Article
- Shear relaxation governs fusion dynamics of biomolecular condensates.Nature communications · 2021Article
- Macromolecular regulators have matching effects on the phase equilibrium and interfacial tension of biomolecular condensates.Protein science : a publication of the Protein Society · 2021Article
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2 authors.
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Abstract
The interfacial tension of phase-separated biomolecular condensates affects their fusion and multiphase organization, and yet how this important property depends on the composition and interactions of the constituent macromolecules is poorly understood. Here we use molecular dynamics simulations to determine the interfacial tension and phase equilibrium of model condensate-forming systems. The model systems consist of binary mixtures of Lennard-Jones particles or chains of such particles. We refer to the two components as drivers and regulators; the former has stronger self-interactions and hence a higher critical temperature (T
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