Evidence map›Paper›PMID 33864396›Full record

Trial reportAlcoholism, clinical and experimental research2021

Alcohol subjective responses in heavy drinkers: Measuring acute effects in the natural environment versus the controlled laboratory setting.

Daniel J Fridberg, Dingcai Cao, Andrea C King

Open access · greenAbstract readClinical TrialComparative Study
In one paragraph

Trial report in Alcoholism, clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Survey measures of subjective response to alcohol are improved by incorporating questions about the intensity of alcohol effects.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
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  16. Drinking context, alcohol use, and subjective responses during binge drinking episodes measured by high-resolution ecological momentary assessment (HR-EMA).Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2023
    Article
  17. Haven't lost the positive feeling: a dose-response, oral alcohol challenge study in drinkers with alcohol use disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Daniel J FridbergDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.ORCID 0000-0003-3451-1418
Dingcai CaoDepartment of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, USA.ORCID 0000-0002-5529-0960
Andrea C KingDepartment of Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, IL, USA.ORCID 0000-0001-5943-7109
University of Chicago · USUniversity of Illinois Chicago · US

Funding

Alcohol Stimulation and Sedation in Binge Drinkers - Renewal 01R01AA013746 · NIAAA · UNIVERSITY OF CHICAGO · PI DANIEL J FRIDBERG, ANDREA C KING · 2003 to 2026
$11.6M
Mobile Phone-Based Alcohol Response Assessment in Young Adult Heavy Drinkers - Resubmission 01R21AA024901 · NIAAA · UNIVERSITY OF CHICAGO · PI FRIDBERG, DANIEL J, KING, ANDREA C · 2016 to 2017
$415k
NIAAA NIH HHS R01 AA013746NIAAA NIH HHS R21 AA024901
6 · The paper itself

Abstract

backgroundFor decades, laboratory alcohol challenges have been the "gold standard" for measuring individual differences in alcohol's subjective effects. However, these approaches are expensive and labor-intensive, making them impractical for large-scale use. This study examined the reliability and validity of a new high-resolution EMA (HR-EMA) ambulatory approach to assessing alcohol use and subjective responses in drinkers' natural environments.

methodsParticipants were 83 young adult heavy social drinkers (58% male; mean ± SD age = 25.4 ± 2.6 years) who completed up to two smartphone-based, 3-h HR-EMA assessments of alcohol use and related subjective responses in their typical drinking environments. Reported alcohol consumption during the HR-EMA periods was used to calculate estimated blood alcohol concentration (eBAC). Subjective effects were measured using the Brief Biphasic Alcohol Effects Scale (B-BAES) and Drug Effects Questionnaire (DEQ). All participants also completed identical measures during a separate, 4 to 5-h laboratory session in which they received a 0.8 g/kg alcohol challenge.

resultsMost natural environment drinking episodes (87%) met or exceeded the threshold for binge drinking (final mean eBAC = 0.12 g/dl). Associations between reported alcohol use and subjective responses on the B-BAES and DEQ were strongest earlier in the drinking events, with fair reliability of reported subjective effects across two HR-EMA episodes (intraclass correlation [ICC] range = 0.46-0.49). There was fair-to-good correspondence between HR-EMA- and laboratory-derived subjective responses (ICC range = 0.49-0.74), even after accounting for differences in alcohol consumption and drinking context. Reported stimulating and rewarding alcohol effects were higher in the ambulatory than laboratory setting, and vice versa for sedating effects.

conclusionsThis study supports the reliability and validity of smartphone-based HR-EMA to measure alcohol use and subjective responses in heavy drinkers' natural environments. These findings lend support to the use of ambulatory HR-EMA as a measure of alcohol subjective responses in risky drinkers when a laboratory protocol is not practical, feasible, or safe.

Indexed as

Mobile ApplicationsAdultAlcohol DrinkingAlcohol-Related DisordersEnvironmentFemaleHumansMaleReproducibility of ResultsYoung AdultBrief Biphasic Alcohol Effects ScaleHeavy DrinkingHigh-Resolution Ecological Momentary AssessmentNatural EnvironmentSubjective Alcohol Response

Identifiers

PMID33864396
PMCPMC8254748
OpenAlexW3152622008

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.