Evidence map›Paper›PMID 33864369›Full record

ArticleSleep2021

Measuring sleep regularity: theoretical properties and practical usage of existing metrics.

Dorothee Fischer, Elizabeth B Klerman, Andrew J K Phillips

Open access · hybridAbstract read
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
17.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 177 citations in OpenAlex.

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  18. Sleep and activity patterns in autism.Autism : the international journal of research and practice · 2026
    Article
  19. Article
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Dorothee FischerDepartment of Sleep and Human Factors Research, Institute for Aerospace Medicine, German Aerospace Center, Cologne, Germany.ORCID 0000-0002-2122-3938
Elizabeth B KlermanDivision of Sleep and Circadian Disorders, Department of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-7402-3171
Andrew J K PhillipsTurner Institute for Brain and Mental Health, School of Psychological Sciences, Monash University, Melbourne, VIC, Australia.ORCID 0000-0003-1156-7056
Brigham and Women's Hospital · USMonash University · AU

Funding

TRANSPLANTATION ANALYSIS OF CIRCADIAN RHYTHMS AND AGINGP01AG009975 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI QUAN, STUART F. · 1991 to 2018
$23.1M
Influence of sleep regularity on circadian rhythms, learning, performance, and moodR01HL128538 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI KLERMAN, ELIZABETH B. · 2016 to 2019
$3.6M
Multi-scale modeling of sleep behaviors in social networksR01GM105018 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A, KLERMAN, ELIZABETH B. · 2013 to 2017
$2.4M
Sleep Duration Required to Restore Performance during Chronic Sleep RestrictionK24HL105664 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI KLERMAN, ELIZABETH B. · 2010 to 2019
$1.8M
NHLBI NIH HHS K24 HL105664NHLBI NIH HHS R01 HL128538NIA NIH HHS P01 AG009975NIGMS NIH HHS R01 GM105018NIH HHS K24HL105664
6 · The paper itself

Abstract

STUDY

objectivesSleep regularity predicts many health-related outcomes. Currently, however, there is no systematic approach to measuring sleep regularity. Traditionally, metrics have assessed deviations in sleep patterns from an individual's average; these traditional metrics include intra-individual standard deviation (StDev), interdaily stability (IS), and social jet lag (SJL). Two metrics were recently proposed that instead measure variability between consecutive days: composite phase deviation (CPD) and sleep regularity index (SRI). Using large-scale simulations, we investigated the theoretical properties of these five metrics.

methodsMultiple sleep-wake patterns were systematically simulated, including variability in daily sleep timing and/or duration. Average estimates and 95% confidence intervals were calculated for six scenarios that affect the measurement of sleep regularity: "scrambling" the order of days; daily vs. weekly variation; naps; awakenings; "all-nighters"; and length of study.

resultsSJL measured weekly but not daily changes. Scrambling did not affect StDev or IS, but did affect CPD and SRI; these metrics, therefore, measure sleep regularity on multi-day and day-to-day timescales, respectively. StDev and CPD did not capture sleep fragmentation. IS and SRI behaved similarly in response to naps and awakenings but differed markedly for all-nighters. StDev and IS required over a week of sleep-wake data for unbiased estimates, whereas CPD and SRI required larger sample sizes to detect group differences.

conclusionsDeciding which sleep regularity metric is most appropriate for a given study depends on a combination of the type of data gathered, the study length and sample size, and which aspects of sleep regularity are most pertinent to the research question.

Indexed as

Circadian RhythmSleep Wake DisordersHumansJet Lag SyndromeSleepcircadian disruptioncircadian misalignmentinter-individual variabilityintra-individual variabilitysleep stabilitysleep variability

Identifiers

PMID33864369
PMCPMC8503839
OpenAlexW3153115623

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.