Evidence map›Paper›PMID 33864283›Full record

ArticleMedical physics2021

Magnetic resonance biomarkers in radiation oncology: The report of AAPM Task Group 294.

Kiaran P McGee, Ken-Pin Hwang, Daniel C Sullivan, John Kurhanewicz, Yanle Hu, Jihong Wang, Wen Li, Josef Debbins, Eric Paulson, Jeffrey R Olsen and 6 more

Open access · greenAbstract read
In one paragraph

Article in Medical physics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 2 countries.

Kiaran P McGeeDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Ken-Pin HwangDepartment of Imaging Physics, Division of Diagnostic Imaging, MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
Daniel C SullivanDepartment of Radiology, Duke University, Durham, North Carolina, USA.
John KurhanewiczDepartment of Radiology, University of California, San Francisco, California, USA.
Yanle HuDepartment of Radiation Oncology, Mayo Clinic, Scottsdale, Arizona, USA.
Jihong WangDepartment of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
Wen LiDepartment of Radiation Oncology, University of Arizona, Tucson, Arizona, USA.
Josef DebbinsDepartment of Radiology, Barrow Neurologic Institute, Phoenix, Arizona, USA.
Eric PaulsonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Jeffrey R OlsenDepartment of Radiation Oncology, University of Colorado Denver - Anschutz Medical Campus, Denver, Colorado, USA.
Chia-Ho HuaDepartment of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Lizette WarnerPhilips Medical Systems, Eindhoven, Netherlands.
Daniel MaDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.
Eduardo MorosDepartment of Radiation Oncology, Moffitt Cancer Center, Tampa, Florida, USA.
Neelam TyagiDepartment of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Caroline ChungDepartment of Radiation Oncology, MD Anderson Cancer Center, University of Texas, Houston, Texas, USA.
The University of Texas MD Anderson Cancer Center · USMayo Clinic · USBarrow Neurological Institute · USDuke University · USMayo Clinic in Arizona · USMedical College of Wisconsin · USMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USPhilips (Netherlands) · NLSt. Jude Children's Research Hospital · USUniversity of Arizona · USUniversity of California, San Francisco · USUniversity of Colorado Anschutz Medical Campus · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeA magnetic resonance (MR) biologic marker (biomarker) is a measurable quantitative characteristic that is an indicator of normal biological and pathogenetic processes or a response to therapeutic intervention derived from the MR imaging process. There is significant potential for MR biomarkers to facilitate personalized approaches to cancer care through more precise disease targeting by quantifying normal versus pathologic tissue function as well as toxicity to both radiation and chemotherapy. Both of which have the potential to increase the therapeutic ratio and provide earlier, more accurate monitoring of treatment response. The ongoing integration of MR into routine clinical radiation therapy (RT) planning and the development of MR guided radiation therapy systems is providing new opportunities for MR biomarkers to personalize and improve clinical outcomes. Their appropriate use, however, must be based on knowledge of the physical origin of the biomarker signal, the relationship to the underlying biological processes, and their strengths and limitations. The purpose of this report is to provide an educational resource describing MR biomarkers, the techniques used to quantify them, their strengths and weakness within the context of their application to radiation oncology so as to ensure their appropriate use and application within this field.

Indexed as

Radiation OncologyBiomarkersMagnetic Resonance ImagingMagnetic Resonance SpectroscopyBiomarkersbiomarker, imaging, MR, QIBA, quantitative, radiation therapy

Identifiers

PMID33864283
PMCPMC8361924
OpenAlexW3154724482

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.