SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2022
No differences in clinical outcome between CMI and Actifit meniscal scaffolds: a systematic review and meta-analysis.
Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical Impact of Meniscal Scaffold Implantation in Patients with Meniscal Tears: A Systematic Review.Clinics in orthopedic surgery · 2025Pooled it
- Safety and Efficacy of a Novel Polyglycolic Acid Meniscal Scaffold for Irreparable Meniscal Tear.Cartilage · 2024Trial
- Meniscus Tissue Engineering Scaffolds: Biomaterials, Biofabrication, and Translation.Polymers · 2026Review
- Translational Progress and Clinical Challenges in Bioengineered Bone and Joint Repair.Biomedicines · 2026Review
- Long-term clinical and MRI outcomes of a polyurethane meniscal scaffold implantation for the treatment of partial meniscal deficiency: A minimum 10-year follow-up study.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- A clinical practice review: augmentation of meniscoligamentous structures for primary prevention of knee joint deterioration.Annals of joint · 2026Review
- Collagen-Based Interventions for Meniscal Tears: A Systematic Review of Clinical Outcomes, Safety, and MRI Findings.Cureus · 2025Review
- Clinical outcomes of artificial meniscus scaffolds for partial meniscus injury: a systematic review and meta-analysis.Knee surgery & related research · 2025Review
- Collagen-Based Scaffolds for Meniscal Repair and Regeneration.Journal of tissue engineering and regenerative medicine · 2025Review
- The Current State of Meniscus Replacements.Current reviews in musculoskeletal medicine · 2024Review
- Addressing meniscal deficiency part 2: An umbrella review of systematic reviews and meta-analyses on meniscal scaffold-based approaches.Journal of experimental orthopaedics · 2024Review
- Biologic Augmentation of Isolated Meniscal Repair.Current reviews in musculoskeletal medicine · 2024Review
- Predictors of Long-term Patient-Reported Outcome Measures After Collagen Meniscal Implant for Partial Meniscal Defects.Orthopaedic journal of sports medicine · 2024Article
- Fibronectin-coated polyurethane meniscal scaffolding supplemented with MSCs improves scaffold integration and proteoglycan production in a rabbit model.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Placement of a polyurethane implant is not associated with a chondroprotective effect: comparative study with cases of isolated medial meniscectomy with at least five years of follow-up.Archives of orthopaedic and trauma surgery · 2023Article
- MRI follow up of bilateral partial meniscal substitution with a demineralized bone block. A case report.Radiology case reports · 2023Article
- Integration of polyurethane meniscus scaffold during ACL revision is not reliable at 5 years despite favourable clinical outcome.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2022Article
- Clinical Replacement Strategies for Meniscus Tissue Deficiency.Cartilage · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the results of two meniscal scaffolds, CMI and Actifit, for the treatment of partial meniscal lesions.
methodsA systematic review was performed on the PubMed, Web of Science, Scopus, Embase, and Cochrane databases in January 2021, including randomized controlled trails (RCTs) and prospective and retrospective observational studies on the clinical results of meniscal scaffolds. A meta-analysis of the clinical results was performed; the rate of failures was recorded, as well as radiological results. The quality of the included studies was assessed with a modified Coleman Methodology Score (CMS).
resultsThe search identified 37 studies (31 in the last 10 years): 2 RCTs, 5 comparative studies, 26 prospective and 4 retrospective series on a total of 1276 patients (472 CMI, 804 Actifit). The quality of evidence was generally low. An overall significant improvement in all clinical scores was documented for both scaffolds. The meta-analysis showed no differences between the two scaffolds in terms of patient reported outcome measures and activity level. The meta-analysis on the risk of failures documented a risk of failures of 7% in the CMI and of 9% in the Actifit group.
conclusionsThere is a growing interest on the results of meniscal scaffolds, with most studies published recently. However, long-term data on the Actifit scaffold and high-level comparative studies are missing. Both CMI and Actifit offered good clinical results with a significant and comparable improvement in symptoms and function, and with a low number of failures over time. Accordingly, with the proper indication, their use may be encouraged in the clinical practice. LEVEL OF EVIDENCE: Level IV.
Indexed as
Identifiers
33864114What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.