ReviewPediatric research2022
Neuroplacentology in congenital heart disease: placental connections to neurodevelopmental outcomes.
Review in Pediatric research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 62 citations in OpenAlex.
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Brain injury in congenital heart disease: pathophysiology, MRI patterns, and perioperative risk factors.Pediatric research · 2026Review
- Maternal congenital heart disease and risk of child developmental vulnerability in early school age: A population-based cohort study.PLoS medicine · 2026Article
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta-Heart Axis.Prenatal diagnosis · 2026Article
- Diminished Late Gestation Placental Volume in Fetal Heart Disease and Implications for Birth Anthropometrics.Journal of cardiovascular development and disease · 2026Article
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Characterizing placental dysfunction with DNA methylation profiling and placental histopathology.Placenta · 2026Article
- Charting normative reference values and Z-scores for MRI-derived in vivo placental growth.Pediatric radiology · 2026Observational
- Placental vascular abnormality is associated with worse neurodevelopmental outcomes for infants with congenital heart disease and genetic abnormality.Early human development · 2026Article
- Unveiling of Placental-Fetal Heart Interplay: A Novel Etiologic and Therapeutic Insight-A Narrative Review.Journal of pregnancy · 2026Review
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Research square · 2025Article
- Neurodevelopment in congenital heart disease: a review of antenatal mechanisms and therapeutic potentials.Pediatric research · 2025Review
- Addressing Survivorship Bias in Neurocognitive Outcomes After Early Complex Cardiac Surgery Using Clustering and Propensity Scores.CJC pediatric and congenital heart disease · 2025Article
- Unmasking the Placenta-Heart Axis: A Comprehensive Review of Placental Abnormalities in Congenital Heart Disease.Diagnostics (Basel, Switzerland) · 2025Review
- Congenital Heart Diseases and Neurodevelopmental Disorders: New Insights Through the DOHaD Hypothesis.JACC. Basic to translational science · 2025Review
- Placental and Fetal In Utero Growth Among Fetuses With Congenital Heart Disease.JAMA network open · 2025Article
- T2*-Relaxometry MRI to Assess Third Trimester Placental and Fetal Brain Oxygenation and Placental Characteristics in Healthy Fetuses and Fetuses With Congenital Heart Disease.Journal of magnetic resonance imaging : JMRI · 2025Article
- Cerebral Microhemorrhages in Children With Congenital Heart Disease: Prevalence, Risk Factors, and Association With Neurodevelopmental Outcomes.Journal of the American Heart Association · 2025Article
- Placental inflammatory response and association with the severity of neonatal hypoxic ischemic encephalopathy.Early human development · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Children with congenital heart disease (CHD) are living longer due to effective medical and surgical management. However, the majority have neurodevelopmental delays or disorders. The role of the placenta in fetal brain development is unclear and is the focus of an emerging field known as neuroplacentology. In this review, we summarize neurodevelopmental outcomes in CHD and their brain imaging correlates both in utero and postnatally. We review differences in the structure and function of the placenta in pregnancies complicated by fetal CHD and introduce the concept of a placental inefficiency phenotype that occurs in severe forms of fetal CHD, characterized by a myriad of pathologies. We propose that in CHD placental dysfunction contributes to decreased fetal cerebral oxygen delivery resulting in poor brain growth, brain abnormalities, and impaired neurodevelopment. We conclude the review with key areas for future research in neuroplacentology in the fetal CHD population, including (1) differences in structure and function of the CHD placenta, (2) modifiable and nonmodifiable factors that impact the hemodynamic balance between placental and cerebral circulations, (3) interventions to improve placental function and protect brain development in utero, and (4) the role of genetic and epigenetic influences on the placenta-heart-brain connection. IMPACT: Neuroplacentology seeks to understand placental connections to fetal brain development. In fetuses with CHD, brain growth abnormalities begin in utero. Placental microstructure as well as perfusion and function are abnormal in fetal CHD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.