ArticleScientific reports2021
The effect of age on the association between diabetes and mortality in adult patients with COVID-19 in Mexico.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Global prevalence and effect of comorbidities and smoking status on severity and mortality of COVID-19 in association with age and gender: a systematic review, meta-analysis and meta-regression.Scientific reports · 2023Pooled it
- Impaired glucose regulation, SARS-CoV-2 infections and adverse COVID-19 outcomes.Translational research : the journal of laboratory and clinical medicine · 2022Pooled it
- Beyond TNM staging: validation of a CT-derived nutritional-inflammatory composite model (RFMmSIS) for prognostication in resectable gastric cancer.BMC cancer · 2026Article
- Comprehensive assessment of COVID-19 case fatality rate and influential factors in Khuzestan Province, Iran: a two-year study.Journal of health, population, and nutrition · 2024Article
- Observational
- Lethality risk markers by sex and age-group for COVID-19 in Mexico: a cross-sectional study based on machine learning approach.BMC infectious diseases · 2023Article
- Magnitude and associated factors of mortality among patients admitted with COVID-19 in Addis Ababa, Ethiopia.PLOS global public health · 2023Article
- Factors associated with covid-19 deaths in the city of Recife, Pernambuco, Brazil, 2020: a cross-sectional study with "Notifique Aqui" system data.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2023Article
- Diabetes as a risk factor of death in hospitalized COVID-19 patients - an analysis of a National Hospitalization Database from Poland, 2020.Frontiers in endocrinology · 2023Article
- Impact of diabetes on COVID-19 patient health outcomes in a vulnerable racial minority community.PloS one · 2023Article
- Mortality Risk Factors for Coronavirus Infection in Hospitalized Adults in Brazil: A Retrospective Cohort Study.International journal of environmental research and public health · 2022Observational
- First and second COVID-19 waves in Brazil: A cross-sectional study of patients' characteristics related to hospitalization and in-hospital mortality.Lancet regional health. Americas · 2022Article
- The Role of Diabetes and Hyperglycemia on COVID-19 Infection Course-A Narrative Review.Frontiers in clinical diabetes and healthcare · 2022Review
- Diabetes and SARS-CoV-2-Is There a Mutual Connection?Frontiers in cell and developmental biology · 2022Review
- COVID-19 Propagation Model Based on Economic Development and Interventions.Wireless personal communications · 2022Article
- Impact of Prediabetes and Type-2 Diabetes on Outcomes in Patients with COVID-19.International journal of endocrinology · 2021Article
- Association of Admission Blood Glucose Level with All-Cause Mortality According to Age in Patients with Community Acquired Pneumonia.International journal of general medicine · 2021Article
- Factors Associated for Mortality of Older People With COVID 19: A Systematic Review and Meta-analysis.Gerontology & geriatric medicineReview
- A new interventional home care model for COVID management: Virtual Covid IP.Diabetes & metabolic syndromeArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diabetes is associated with severe COVID-19 and mortality. The aim of the present study was to determine the effect of age on the association between diabetes and mortality in patients with laboratory-confirmed COVID-19 in Mexico. This retrospective cohort study involved patients aged 20 years or older with symptoms of viral respiratory disease who were screened for SARS-CoV-2 infection across the System of Epidemiological Surveillance of Viral Respiratory Disease in Mexico from January 1 through November 4, 2020. Cox proportional-hazard regression was used to calculate the hazard ratio for 28-day mortality and its 95% confidence interval (CI). Among 757,210 patients with COVID-19 (outpatients and inpatients), 120,476 (16%) had diabetes and 80,616 died. Among 878,840 patients without COVID-19 (those who tested negative for SARS-CoV-2 infection), 88,235 (10.0%) had diabetes and 20,134 died. Among patients with COVID-19, diabetes was associated with a hazard ratio for death of 1.49 (95% CI 1.47-1.52), adjusting for age, sex, smoking habit, obesity, hypertension, immunodeficiency, and cardiovascular, pulmonary, and chronic renal disease. The strength of the association decreased with age (trend test: P = 0.004). For example, the adjusted hazard ratio for death was 3.12 (95% CI 2.86-3.40) for patients 20-39 years of age; in contrast, the adjusted hazard ratio of death for patients 80 years of age or older was 1.11 (95% CI 1.06-1.16). The adjusted hazard ratios were 1.66 (95% CI 1.58-1.74) in outpatients and 1.14 (95% CI 1.12-1.16) in inpatients. In hospitalized patients 80 years of age or older, no association was observed between diabetes and COVID-19-related mortality (adjusted hazard ratio: 1.03; 95% CI 0.98-1.08). Among patients without COVID-19, the adjusted hazard ratio for death was 1.78 (95% CI 1.73-1.84). In conclusion, in adult patients with COVID-19 in Mexico, the risk of death associated with diabetes decreased with age. No association between diabetes and mortality was observed among inpatients 80 years of age or older. Our findings should be verified in other populations.
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