Evidence map›Paper›PMID 33863910›Full record

ArticleScientific reports2021

Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.

Thando Shabangu, Hung-Lun Chen, Zi-Hui Zhuang, Alessandra Pierani, Chien-Fu F Chen, Shen-Ju Chou

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Thando ShabanguMolecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan.
Hung-Lun ChenGraduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.
Zi-Hui ZhuangInstitute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
Alessandra PieraniImagine Institute, Team Genetics and Development of the Cerebral Cortex, Université de Paris, F-75015, Paris, France.
Chien-Fu F ChenMolecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. t70cyy@yahoo.com.
Shen-Ju ChouMolecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, Taiwan. schou@gate.sinica.edu.tw.
Institute of Cellular and Organismic Biology, Academia Sinica · TWNational Defense Medical Center · TWInstitut de Psychiatrie et Neurosciences de Paris · FRInstitute of Molecular Biology, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The piriform cortex (PC) is a major cortical processing center for the sense of smell that receives direct inputs from the olfactory bulb. In mice, the PC consists of three neuronal layers, which are populated by cells with distinct developmental origins. One origin of PC neurons is the pool of Dbx1-expressing neural progenitors located in the ventral pallium at the pallial-subpallial boundary. Since the precise mechanisms of PC neuron development are largely unknown, we sought to define the distribution, timing of neurogenesis, morphology and projection patterns of PC neurons from the Dbx1 lineage. We found that Dbx1-lineage neurons are preferentially distributed in layer 2 and enriched in the ventral portion of the PC. Further, Dbx1 neurons are early-born neurons and contribute to most neuronal subtypes in the PC. Our data also revealed an enrichment of Dbx1-lineage neurons in the ventral anterior PC that project to the orbitofrontal cortex. These findings suggest a specific association between the developmental origin of PC neurons and their neuronal properties.

Indexed as

SmellAnimalsGene ExpressionHomeodomain ProteinsMiceMice, KnockoutNeurogenesisNeuronsOlfactory BulbPiriform CortexStem CellsDbx1 protein, mouseHomeodomain Proteins

Identifiers

PMID33863910
PMCPMC8052341
OpenAlexW3114362021

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.