Evidence map›Paper›PMID 33863906›Full record

ArticleNature communications2021

Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells.

Hristo Georgiev, Changwei Peng, Matthew A Huggins, Stephen C Jameson, Kristin A Hogquist

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  5. MAIT cells: Conserved watchers on the wall.The Journal of experimental medicine · 2025
    Review
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  7. Protective effects ofFrontiers in pharmacology · 2024
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  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Development of αβ T Cells with Innate Functions.Advances in experimental medicine and biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Hristo GeorgievCenter for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0003-1369-960X
Changwei PengCenter for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Matthew A HugginsCenter for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Stephen C JamesonCenter for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.ORCID http://orcid.org/0000-0001-9137-1146
Kristin A HogquistCenter for Immunology and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA. hogqu001@umn.edu.ORCID http://orcid.org/0000-0001-9963-5687
University of Minnesota · US

Funding

TCR signal strength in thymic selectionR37AI039560 · NIAID · UNIVERSITY OF MINNESOTA · PI HOGQUIST, KRISTIN A. · 2012 to 2021
$3.7M
NIAID NIH HHS R37 AI039560
6 · The paper itself

Abstract

Conventional T cells are selected by peptide-MHC expressed by cortical epithelial cells in the thymus, and not by cortical thymocytes themselves that do not express MHC I or MHC II. Instead, cortical thymocytes express non-peptide presenting MHC molecules like CD1d and MR1, and promote the selection of PLZF

Indexed as

Immunity, InnateAnimalsCell DifferentiationHistocompatibility Antigens Class IIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicMucosal-Associated Invariant T CellsNatural Killer T-CellsPromyelocytic Leukemia Zinc Finger ProteinThymocytesThymus GlandHistocompatibility Antigens Class IIntracellular Signaling Peptides and ProteinsNLRC5 protein, mousePromyelocytic Leukemia Zinc Finger ProteinZbtb16 protein, mouse

Identifiers

PMID33863906
PMCPMC8052364
OpenAlexW3153755568

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.