ArticleNature communications2021
Field and classroom initiatives for portable sequence-based monitoring of dengue virus in Brazil.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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44citing papers in PubMed, 1 pooled it
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- SARS-CoV-2 Genomic Surveillance in Brazil: A Systematic Review with Scientometric Analysis.Viruses · 2022Pooled it
- Nanopore Sequencing for Chikungunya Virus: Principles and Application.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Arbovirus co-circulation and epidemiological convergence in a changing climate: challenges for surveillance, diagnosis and public health preparedness.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026Review
- First whole-genome detection of dengue virus in urban Aedes aegypti from Southern Brazil.PLoS neglected tropical diseases · 2026Article
- Global Genomic Surveillance: On-The-Ground Responses.Current topics in microbiology and immunology · 2026Review
- Uncovering DENV, CHIKV, and ZIKV in Urban Wastewater in Brazil Through Genomic and Molecular Screening.Microorganisms · 2025Article
- Establishing a dengue genomic monitoring in Cuba: uncovering virus dynamics to enhance local response.IJID regions · 2025Article
- Dynamics and genetic variation of dengue virus serotypes circulating during the 2022 outbreak in Karachi.Scientific reports · 2025Article
- Article
- Infectivity and Dissemination of Dengue Virus-1 in DifferentTropical medicine and infectious disease · 2025Article
- Global trends in the application of nanopore sequencing technology in the detection of infectious disease pathogens: a bibliometric analysis from 2014 to 2024.Frontiers in medicine · 2025Article
- Tracing the Origin, Spread, and Molecular Evolution of Dengue Type 1 Cases That Occurred in Northern Italy in 2023.Pathogens (Basel, Switzerland) · 2024Article
- Dengue virus transmission in Italy: historical trends up to 2023 and a data repository into the future.Scientific data · 2024Article
- Article
- Retrospective epidemiologic and genomic surveillance of arboviruses in 2023 in Brazil reveals high co-circulation of chikungunya and dengue viruses.BMC medicine · 2024Article
- Exploring Dengue Infection in a Vaccinated Individual: Preliminary Molecular Diagnosis and Sequencing Insights.Viruses · 2024Article
- A new lineage nomenclature to aid genomic surveillance of dengue virus.PLoS biology · 2024Article
- North-south pathways, emerging variants, and high climate suitability characterize the recent spread of dengue virus serotypes 2 and 3 in the Dominican Republic.BMC infectious diseases · 2024Article
- Exploring the urban arbovirus landscape in Rio de Janeiro, Brazil: transmission dynamics and patterns of disease spread.Lancet regional health. Americas · 2024Article
- A new lineage nomenclature to aid genomic surveillance of dengue virus.medRxiv : the preprint server for health sciences · 2024Article
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Authors and funding
61 authors at 20 institutions in 13 countries.
Talita Émile Ribeiro Adelino *Laboratório Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0002-1471-0084
Marta Giovanetti *Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil. giovanetti.marta@gmail.com.ORCID 0000-0002-5849-7326
Vagner Fonseca *Laboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-5521-6448
Joilson XavierLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0003-3916-2018
Álvaro Salgado de AbreuLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Valdinete Alves do NascimentoLaboratório de Ecologia de Doenças Transmissíveis na Amazônia, Instituto Leônidas e Maria Deane, Fiocruz, Manaus, Amazonas, Brazil.
Luiz Henrique Ferraz DemarchiLaboratório Central de Saúde Pública do Estado de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Marluce Aparecida Assunção OliveiraLaboratório Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.
Vinícius Lemes da SilvaLaboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, Goiás, Brazil.
Arabela Leal E Silva de MelloLaboratório Central de Saúde Pública Professor Gonçalo Moniz, Salvador, Bahia, Brazil.
Gabriel Muricy CunhaSecretaria de Saúde do Estado da Bahia, Salvador, Bahia, Brazil.
Roselene Hans SantosLaboratório Central de Saúde Pública Dr. Milton Bezerra Sobral, Recife, Pernambuco, Brazil.
Elaine Cristina de OliveiraLaboratório Central de Saúde Pública do Estado de Mato Grosso, Cuiabá, Mato Grosso, Brazil.
Jorge Antônio Chamon JúniorLaboratório Central de Saúde Pública do Distrito Federal, Brasília, Distrito Federal, Brazil.
Felipe Campos de Melo IaniLaboratório Central de Saúde Pública do Estado de Minas Gerais, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.ORCID 0000-0002-3629-8529
Ana Maria Bispo de FilippisLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
André Luiz de AbreuCoordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Ronaldo de JesusCoordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Carlos Frederico Campelo de AlbuquerqueOrganização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Distrito Federal, Brazil.
Jairo Mendez RicoOrganização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Distrito Federal, Brazil.
Rodrigo Fabiano do Carmo SaidOrganização Pan-Americana da Saúde/Organização Mundial da Saúde, Brasília, Distrito Federal, Brazil.
Joscélio Aguiar SilvaCoordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Noely Fabiana Oliveira de MouraCoordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Priscila LeiteCoordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Lívia Carla Vinhal FrutuosoCoordenação Geral das Arboviroses, Secretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.ORCID 0000-0001-7926-1075
Simone Kashima HaddadFundação Hemocentro de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Alexander MartínezGorgas Memorial Institute for Health Studies, Panama, Panama.
Fernanda Khouri BarretoUniversidade Federal da Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0002-0088-9036
Cynthia Carolina VazquezLaboratorio Central de Salud Pública, Asunción, Paraguay.
Rivaldo Venâncio da CunhaFundação Oswaldo Cruz, Bio-Manguinhos, Rio de Janeiro, Rio de Janeiro, Brazil.
Emerson Luiz Lima AraújoCoordenação Geral dos Laboratórios de Saúde Pública, Secretaria de Vigilância em Saúde, Ministério da Saúde, Brasília, Distrito Federal, Brazil.ORCID 0000-0002-7684-2883
Stephane Fraga de Oliveira TostaLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Allison de Araújo FabriLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Flávia Löwen Levy ChalhoubLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Poliana da Silva LemosInstituto Evandro Chagas, Belém, Pará, Brazil.ORCID 0000-0003-1271-8549
Fernanda de Bruycker-NogueiraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Gislene Garcia de Castro LichsLaboratório Central de Saúde Pública do Estado de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Marina Castilhos Souza Umaki ZardinLaboratório Central de Saúde Pública do Estado de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Fátima María Cardozo SegoviaInstituto de Investigaciones en Ciencias de la Salud, San Lorenzo, Paraguay.
Crhistinne Cavalheiro Maymone GonçalvesSecretaria de Estado de Saúde de Mato Grosso do Sul, Campo Grande, Mato Grosso do Sul, Brazil.
Zoraida Del Carmen Fernandez GrilloFundação Oswaldo Cruz, Campo Grande, Mato Grosso do Sul, Brazil.
Svetoslav Nanev SlavovFundação Hemocentro de Ribeirão Preto, Ribeirão Preto, São Paulo, Brazil.
Luiz Augusto PereiraLaboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, Goiás, Brazil.
Ana Flávia MendonçaLaboratório Central de Saúde Pública Dr. Giovanni Cysneiros, Goiânia, Goiás, Brazil.
Felicidade Mota PereiraLaboratório Central de Saúde Pública Professor Gonçalo Moniz, Salvador, Bahia, Brazil.
Jurandy Júnior Ferraz de MagalhãesLaboratório Central de Saúde Pública Dr. Milton Bezerra Sobral, Recife, Pernambuco, Brazil.
Agenor de Castro Moreira Dos Santos JúniorLaboratório Central de Saúde Pública do Distrito Federal, Brasília, Distrito Federal, Brazil.
Maricélia Maia de LimaSecretaria de Saúde de Feira de Santana, Feira de Santana, Bahia, Brazil.ORCID 0000-0003-2320-4340
Rita Maria Ribeiro NogueiraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Aristóteles Góes-NetoInstituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Vasco Ariston de Carvalho AzevedoInstituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Dario Brock RamalhoSecretaria de Saúde do Estado de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Wanderson Kleber OliveiraHospital das Forças Armadas, Brasília, Distrito Federal, Brazil.ORCID 0000-0002-9662-1930
Eduardo Marques MacarioSecretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Arnaldo Correia de MedeirosSecretaria de Vigilância em Saúde/Ministério da Saúde, Brasília, Distrito Federal, Brazil.
Victor PimentelInstituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Lisboa, Portugal.
Latin American Genomic Surveillance Arboviral Network
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, University of Sydney, Sydney, NSW, Australia.ORCID 0000-0001-9596-3552
Tulio de OliveiraKwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.
José LourençoDepartment of Zoology, Peter Medawar Building, University of Oxford, Oxford, UK. jose.lourenco@zoo.ox.ac.uk.ORCID 0000-0002-9318-2581
Luiz Carlos Junior AlcantaraLaboratório de Flavivírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil. luiz.alcantara@ioc.fiocruz.br.ORCID 0000-0002-6769-9931
Fundação Oswaldo Cruz · BRUniversidade Federal de Minas Gerais · BRMinistério da Saúde · BRInstituto Conmemorativo Gorgas de Estudios de la Salud · PAUniversidade de São Paulo · BRUniversidade Federal de Ouro Preto · BREzequiel Dias Foundation · BRInstituto Evandro Chagas · BRUniversidade Estadual de Feira de Santana · BRUniversidade Federal do Rio de Janeiro · BRFundação de Amparo à Pesquisa do Estado de Minas Gerais · BRPan American Health Organization (Brasil) · BRUniversidade de Brasília · BRFundação Hemopa · BRGoverno do Distrito Federal · BRGoverno do Estado de Mato Grosso · BRInstituto Adolfo Lutz · BRInstituto Costarricense de Investigación y Enseñanza en Nutrición y Salud · CRUniversidade do Estado do Rio Grande do Norte · BRUniversidade Federal de Pernambuco · BR
Funding
University of Washington Arboviral Research Network (UWARN)U01AI151698 · NIAID · UNIVERSITY OF WASHINGTON · PI Michael Gale, PETER MACGARR RABINOWITZ · 2020 to 2026
$13.3MNIAID NIH HHS U01 AI151698
Abstract
Brazil experienced a large dengue virus (DENV) epidemic in 2019, highlighting a continuous struggle with effective control and public health preparedness. Using Oxford Nanopore sequencing, we led field and classroom initiatives for the monitoring of DENV in Brazil, generating 227 novel genome sequences of DENV1-2 from 85 municipalities (2015-2019). This equated to an over 50% increase in the number of DENV genomes from Brazil available in public databases. Using both phylogenetic and epidemiological models we retrospectively reconstructed the recent transmission history of DENV1-2. Phylogenetic analysis revealed complex patterns of transmission, with both lineage co-circulation and replacement. We identified two lineages within the DENV2 BR-4 clade, for which we estimated the effective reproduction number and pattern of seasonality. Overall, the surveillance outputs and training initiative described here serve as a proof-of-concept for the utility of real-time portable sequencing for research and local capacity building in the genomic surveillance of emerging viruses.
Indexed as
Epidemiological MonitoringBrazilDengueDengue VirusEpidemicsFeasibility StudiesGenetic VariationGenome, ViralHumansMobile Health UnitsMolecular EpidemiologyMolecular TypingPhylogenyProof of Concept StudyReal-Time Polymerase Chain ReactionRetrospective StudiesRNA, Viral
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