Evidence map›Paper›PMID 33863824›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2021

The Latest Advances in Imaging Crosstalk Between the Immune System and Fibrosis in Cardiovascular Disease.

Gyu Seong Heo, Lanlan Lou, Deborah Sultan, Yongjian Liu

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Feasibility ofScientific reports · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Gyu Seong HeoMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Lanlan LouMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Deborah SultanMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.
Yongjian LiuMallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri yongjianliu@wustl.edu.
Mallinckrodt (United States) · US

Funding

Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
NHLBI NIH HHS R35 HL145212
6 · The paper itself

Abstract

Inflammation and fibrosis are hallmarks of tissue repair processes and organ failure progression in cardiovascular diseases. Paradigm-shifting research on diverse immune cell populations within the cardiovascular system have enabled discovery of new biomarkers fostering development of diagnostic and therapeutic agents at the molecular level to better manage cardiovascular diseases. To date, a variety of molecular imaging agents have been developed to visualize the biomarkers expressed on immune cells and fibroblasts within their crosstalk network, which drives the pathogenesis of fibrosis triggered by both innate and adaptive immunity. Herein, key biomarkers upregulated in the immune-fibrosis axis are discussed. The promising molecular imaging agents to reveal this critical pathologic process are summarized.

Indexed as

Cardiovascular DiseasesFibrosisImmune SystemMolecular ImagingAnimalsBiomarkersHumansBiomarkerscardiovascular diseasesfibrosisimmune systeminflammationmolecular imaging

Identifiers

PMID33863824
PMCPMC8724900
OpenAlexW3154239942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.