Evidence map›Paper›PMID 33863790›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

The Murine MHC Class II Super Enhancer

Parimal Majumder, Joshua T Lee, Benjamin G Barwick, Dillon G Patterson, Alexander P R Bally, Christopher D Scharer, Jeremy M Boss

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Parimal MajumderDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Joshua T LeeDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0003-1941-8282
Benjamin G BarwickDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-9810-3566
Dillon G PattersonDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-6053-5216
Alexander P R BallyDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA.ORCID 0000-0001-7716-8504
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA jmboss@emory.edu.ORCID 0000-0002-2432-1840
Emory University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008490 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2022
$8.0M
Regulation of MHC Class II GenesR01GM047310 · NIGMS · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 1993 to 2015
$4.6M
Role of the DR/DQ super enhancer in MHC-II expressionR01AI153102 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2020 to 2024
$2.4M
Role of HLA/MHCII in Parkinson's Disease PathogenesisR01NS092122 · NINDS · EMORY UNIVERSITY · PI BOSS, JEREMY M., TANSEY, MARIA DE LOURDES GAMEZ · 2015 to 2019
$1.8M
Epigenetic Programming of B cell Terminal DifferentiationF31AI112261 · NIAID · EMORY UNIVERSITY · PI BARWICK, BENJAMIN GABRIEL · 2014 to 2016
$120k
NIAID NIH HHS F31 AI112261NIAID NIH HHS R01 AI153102NIGMS NIH HHS R01 GM047310NIGMS NIH HHS T32 GM008490NINDS NIH HHS R01 NS092122
6 · The paper itself

Abstract

In both humans and mice, CTCF-binding elements form a series of interacting loops across the MHC class II (MHC-II) locus, and CTCF is required for maximal MHC-II gene expression. In humans, a CTCF-bound chromatin insulator termed

Indexed as

AnimalsCCCTC-Binding FactorGenes, MHC Class IIHLA-DQ alpha-ChainsHLA-DRB1 ChainsMiceMice, Inbred C57BLMice, KnockoutCCCTC-Binding FactorHLA-DQA1 antigenHLA-DQ alpha-ChainsHLA-DRB1 Chains

Identifiers

PMID33863790
PMCPMC8062291
OpenAlexW3155888626

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.